A conserved structural motif shared by EIAV gp90 and HIV gp120

作     者：LI Huiguang1, TONG Xiao1,2, SHEN Tao1, SHEN Rongxian3, ZHANG Xiaoyan1 & SHAO Yiming1 1. Department of Research on Virology and Immunology, National Cen- ter for AIDS/STD Control and Prevention, CDC, Beijing 100052, China 2. Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China 3. Department of Research on EIAV, Harbin Veterinary Research Insti- tute, Harbin 150001, China 

出 版 物：《Science Bulletin》 (科学通报(英文版))

年 卷 期：2005年第20期

页      面：139-140页

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

主　　题：EIAV HIV N-glycosylation epitope gp120 gp90. 

摘      要：Both HIV and EIAV belong to the retroviridae family and lentivirus genus. They share considerable simi- larity at gene structural and component level. Hotzel pro- posed that two variable regions and surrounding amino acids of EIAV gp90 might adopt the same topology as V1, V2 and bridging sheet of HIV gp120. These regions map to V3, V4 and surrounding amino acids of EIAV gp90. Based on this proposal, we further analyzed the distribution profile of N-glycosylation site and linear epitope for EIAV gp90 and HIV gp120 at these regions. Our results demonstrated that EIAV gp90 and HIV gp120 are highly similar at these two aspects. Most likely, V3, V4 and surrounding amino acids of EIAV gp90 adopt the same topology structure as V1, V2 and bridging sheet of HIV gp120.