INSTRUCTIONS TO AUTHORS

作     者：Tae-Sun Ha 

作者机构：Department of PediatricsCollege of MedicineChungbuk National UniversityCheongju 361-240South Korea 

出 版 物：《World Journal of Nephrology》 (世界肾病学杂志（英文版）)

年 卷 期：2013年第2卷第1期

页      面：1-10页

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

主　　题：Adaptor protein Podocyte Slit diaphragm Proteinuria Signaling 

摘      要：Podocytes covering the glomerular basement mem-brane over the glomerular capillary consist of three morphologically and functionally different segments, the cell body, major processes and extending finger-like foot processes （FPs）. The FPs of neighboring podo-cytes are connected by a continuous adherent junction structure named the slit diaphragm （SD）. The extracel-lular SD is linked to the intracellular, a highly dynamic, cytoskeleton through adaptor proteins. These adaptor proteins, such as CD2-associated protein, zonula oc-cludens 1, β-catenin, Nck and p130Cas, located at the intracellular SD insertion area near lipid rafts, have important structural and functional roles. Adaptor pro-teins in podocytes play important roles as a structural component of the podocyte structure, linking the SD to the cytoskeletal structure and as a signaling platform sending signals from the SD to the actin cytoskeleton. This review discusses the roles of adaptor proteins in the podocyte cytoskeletal structure and signaling from the SD to the actin cytoskeleton.