Harnessing pharmacological knowledge for personalized medicine and pharmacotyping: Challenges and lessons learned

作     者：Ioannis S Vizirianakis 

作者机构：Laboratory of Pharmacology Department of Pharmaceutical Sciences School of Health Sciences Aristotle University of Thessaloniki GR-54124 Thessaloniki Greece 

出 版 物：《World Journal of Pharmacology》 (世界药理学杂志)

年 卷 期：2014年第3卷第4期

页      面：110-119页

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

主　　题：遗传组成 现代药理学 治疗方法 临床分析 

摘      要：The contribution of the genetic make-up to an individual s capacity has long been recognized in modern pharmacology as a crucial factor leading to therapy inefficiency and toxicity, negatively impacting the economic burden of healthcare and restricting the monitoring of diseases. In practical terms, and in order for drug prescription to be improved toward meeting the personalized medicine concept in drug delivery, the maximum clinical outcome for most, if not all, patients must be achieved, i.e., pharmacotyping. Such a direction although promising and of high expectation from the society, it is however hardly to be afforded for healthcare worldwide. To overcome any existed hurdles, this means that practical clinical utility of personalized medicine decisions have to be documented and validated in the clinical setting. The latter implies for drug delivery the efficient implementation of previously gained in vivo pharmacology experience with pharmacogenomics knowledge. As an approach to work faster and in a more productive way, the elaboration of advanced physiologically based pharmacokinetics models is discussed. And in better clarifying this topic, the example of tamoxifen is thoroughly presented. Overall, pharmacotyping represents a major challenge in modern therapeutics for which pharmacologists need to work in successfully fulfilling this task.