Total Synthesis of a Hyperbranched N-Linked Hexasaccharide Attached to ATCV-1 Major Capsid Protein without Precedent
作者机构:State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityXue Yuan Road No.38Beijing 100191China State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 200031China
出 版 物:《Chinese Journal of Chemistry》 (中国化学(英文版))
年 卷 期:2019年第37卷第1期
页 面:42-48页
核心收录:
基 金:the National Key R&D Program of China (Grant No. 2018YFA0507602) the National Natural Science Foundation of China (Nos.21572012,21772006) the State Key Laboratory of Drug Research (No.SIMM1803KF-02)
摘 要:Summary of main observation and conclusion The N-glycans attached to some chloroviruses comprise a hyperbranched core structure without *** are interested in the chemical synthesis of the hexasaccharide attached to ATCV-1 (Acanthocystis turfacea Chlorella virus 1)for its distinct *** exploring four routes,the target hexasaccharide 2 was successfully synthesized for the first time in overall 10% yield over 8 steps from thioglycoside building *** synthetic protocol is characterized by the three-component one-pot glycosylation and the regioselective glycosylation *** disclosed synthetic approach to this new type of N-glycans will facilitate the in-depth understanding of their biological functions.