Total Synthesis of a Hyperbranched N-Linked Hexasaccharide Attached to ATCV-1 Major Capsid Protein without Precedent

作     者：Yong-Shi Wang Yong Wu De-Cai Xiong Xin-Shan Ye 

作者机构：State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityXue Yuan Road No.38Beijing 100191China State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 200031China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2019年第37卷第1期

页      面：42-48页

核心收录：

学科分类：07[理学] 0703[理学-化学] 

基　　金：the National Key R&D Program of China (Grant No. 2018YFA0507602) the National Natural Science Foundation of China (Nos.21572012,21772006) the State Key Laboratory of Drug Research (No.SIMM1803KF-02) 

主　　题：chemical routes functions 

摘      要：Summary of main observation and conclusion The N-glycans attached to some chloroviruses comprise a hyperbranched core structure without *** are interested in the chemical synthesis of the hexasaccharide attached to ATCV-1 (Acanthocystis turfacea Chlorella virus 1)for its distinct *** exploring four routes,the target hexasaccharide 2 was successfully synthesized for the first time in overall 10% yield over 8 steps from thioglycoside building *** synthetic protocol is characterized by the three-component one-pot glycosylation and the regioselective glycosylation *** disclosed synthetic approach to this new type of N-glycans will facilitate the in-depth understanding of their biological functions.