Phenotyping emphysema and airways disease: Clinical value of quantitative radiological techniques

作     者：Diana Crossley Alice Turner Deepak Subramanian 

作者机构：Centre for Translational Inflam-mation ResearchQueen Elizabeth Hospital Birmingham Royal Derby Hospital 

出 版 物：《World Journal of Respirology》 (世界呼吸病学杂志)

年 卷 期：2017年第7卷第1期

页      面：1-16页

学科分类：10[医学] 

主　　题：Chronic obstructive pulmonary disease Alpha one antitrypsin deficiency Computed tomography Densitometry Phenotype Spirometry Magnetic resonance imaging 

摘      要：The pathophysiology of chronic obstructive pulmonary disease(COPD) and Alpha one antitrypsin deficiency is increasingly recognised as complex such that lung function alone is insufficient for early detection, clinical categorisation and dictating management. Quantitative imaging techniques can detect disease earlier and more accurately, and provide an objective tool to help phenotype patients into predominant airways disease or emphysema. Computed tomography provides detailed information relating to structural and anatomical changes seen in COPD, and magnetic resonance imaging/nuclear imaging gives functional and regional information with regards to ventilation and perfusion. It is likely imaging will become part of routine clinical practice, and an understanding of the implications of the data is essential. This review discusses technical and clinical aspects of quantitative imaging in obstructive airways disease.