Monitoring transient nanoparticle interactions with liposome-confined plasmonic transducers

作     者：Tianhong Chen Xiao Wang Mohammad Hossein Alizadeh Björn M.Reinhard 

作者机构：Department of Chemistry and The Photonics CenterBoston University590 Commonwealth AvenueBostonMA 02215USA 

出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)

年 卷 期：2017年第3卷第1期

页      面：341-348页

核心收录：

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：This work was supported by the National Institutes of Health(NIH)through Grant No.R01CA138509(to BMR) 

主　　题：gold nanoparticles molecular rulers plasmon plasmon coupling plasmon hybridization plasmon rulers self-assembly 

摘      要：The encapsulation of individual pairs of plasmonic nanoparticles(NPs)in liposomes is introduced as a new strategy for utilizing plasmon coupling to monitor interactions between co-confined NPs in a nanoconfinement that ensures high local NP *** apply the approach to monitor transient binding contacts between noncovalently tethered 55 nm diameter gold NPs,which were functionalized with cytosine(C)-rich DNAs,in acidic and mildly basic buffer *** pH=8,a rich spectral dynamics indicates DNA-mediated transient binding and unbinding of co-confined NPs due to weak attractive interparticle interactions.A decrease in pH from 8 to 4 is observed to favor the associated state for some co-confined NPs,presumably due to a stabilization of the bound dimer configuration through noncanonical C-C^(+)bonds between the DNA-functionalized *** nanoemitters whose spectral response switches in response to chemical cues(in this work pH)represent optical transducers with a rich application space in chemical sensing,cell analysis and nanophotonics.