Submucosal injection of platelet-rich plasma in endoscopic resection of large sessile lesions

作     者：Vicente Lorenzo-Zuniga Vicente Moreno de Vega Ramón Bartolí Ingrid Marín NoemíCaballero Ignacio Bon Jaume Boix 

作者机构：Department of Gastrointestinal EndoscopyUniversity Hospital Germans Trias/CIBERehdBarcelona 08916Spain 

出 版 物：《World Journal of Gastrointestinal Endoscopy》 (世界胃肠内镜杂志（英文版）（电子版）)

年 卷 期：2018年第10卷第11期

页      面：348-353页

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：Platelet-rich plasma endoscopic mucosal resection submucosal injection large lesions 

摘      要：AIM To prospectively evaluate the efficacy of submucosal injection of platelet-rich plasma(PRP) on endoscopic resection of large sessile lesions.METHODS Eleven patients were submitted to endoscopic mucosal resection(EMR) with prior injection of PRP, obtained at the time of endoscopy. Patients were followed during 1 mo. The incidence of adverse events(delayed bleeding or perforation) and the percentage of mucosal healing(MHR) after 4 wk were registered. RESULTS EMR was performed in 11 lesions(46.4 mm ± 4 mm, range 40-70 mm). Delayed bleeding or perforation was not observed in any patient. Mean ulcerated area atbaseline was 22.7 cm^2 ± 11.7 cm^2 whereas at week 4 were 2.9 cm^2 ± 1.5 cm^2. Patients treated with PRP showed a very high MHR after 4 wk(87.5%). CONCLUSION PRP is an easy-to-obtain solution with proven and favourable biological activities that could be used in advanced endoscopic resection.