Clinical features and determinants of VO_(2peak) in de novo heart transplant recipients
Clinical features and determinants of VO_(2peak) in de novo heart transplant recipients作者机构：Department of Cardiology Oslo University Hospital the Norwegian Health Association Faculty of Medicine University of Oslo KG Jebsen Center for Cardiac Research and Center for Heart Failure Research University of Oslo Department of Cardiology Sahlgrenska University Hospital Department of Physical Therapy Sahlgrenska University Hospital Department of Cardiology Bispebjerg University Hospital Department of Cardiology Rigshospitalet University Hospital
出 版 物：《World Journal of Transplantation》 (世界移植杂志)
年 卷 期：2018年第8卷第5期
页 面：188-197页
学科分类：10[医学]
基 金：Supported by the Norwegian Health Association,No.12906 Scandiatransplant the South-Eastern Norway Regional Authority,No.2013111
主 题：Cardiopulmonary exercise testing Early VO2peak De novo heart transplant Health related quality of life Muscle strength
摘 要：AIM To study exercise capacity and determinants of early peak oxygen consumption(VO_(2peak)) in a cohort of de novo heart transplant(HTx) recipients. METHODS To determine possible central(chronotropic responses, cardiopulmonary and hemodynamic function) and peripheral factors(muscular exercise capacity and body composition) predictive of VO_(2peak), a number of different measurements and tests were performed, as follows: Cardiopulmonary exercise testing(CPET) was performed mean 11 wk after surgery in 81 HTx recipients 18 years and was measured with breath by breath gas exchange on a treadmill or bicycle ergometer. Metabolic/respiratory measures include VO_(2peak) and VE/VCO2 slope. Additional measures included muscle strength testing, bioelectrical impedance analysis, echocardiography, blood sampling and health-related quality of life. Based on the VO_(2peak)(mL/kg per minute) median value, the study population was divided into two groups defined as a low-capacity group and a high-capacity group. Potential predictors were analyzed using multiple regression analysis with VO_(2peak)(L/min) as the dependent *** The mean ± standard deviation(SD) age of the total study population was 49 ± 13 years, and 73% were men. This de novo HTx cohort demonstrated a median VO_(2peak) level of 19.4 mL/kg per min at 11 ± 1.8 wk postHTx. As compared with the high-capacity group, the low-capacity group exercised for a shorter time, had lower maximal ventilation, O_2 pulse, peak heart rate and heart rate reserve, while the VE/VCO_2 slope was higher. The low-capacity group had less muscle strength and muscular exercise capacity in comparison with the highcapacity group. In order of importance, O_2 pulse, heart rate reserve, muscular exercise capacity, body mass index, gender and age accounted for 84% of the variance in VO_(2peak)(L/min). There were no minor or major serious adverse events during the CPET. CONCLUSION Although there is great individual variance among de novo
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