Molecular biomarkers of cell proliferation in ameloblastomas
Molecular biomarkers of cell proliferation in ameloblastomas作者机构：Molecular PathologySchool of DentistryUniversidad de la República (UDELAR)Montevideo 11600Uruguay Biology DepartmentCBCUniversidad de Buenos Aires (UBA)Buenos Aires C1122AAHArgentina Anatomy PathologySchool of DentistryUniversidad de la República (UDELAR)Montevideo 11600Uruguay Biotechnology Laboratory Solutions (LASOBIOTC)Montevideo 11600Uruguay
出 版 物：《World Journal of Stomatology》 (世界口腔医学杂志)
年 卷 期：2013年第2卷第4期
页 面：79-85页
学科分类：10[医学]
主 题：Ameloblastoma Ki-67 Proliferating cell nuclear antigen cyclin D1 DNA topoisomerase
摘 要：Cell proliferation is a vital biological process that is important for all living organisms because of its role in growth and the maintenance of tissue *** control of this important process differs greatly among benign and malignant neoplasms,and the evaluation of cell proliferation in neoplasms has become a common tool used by pathologists to provide useful information pertaining to diagnosis,clinical behavior,and *** usefulness of information regarding cell proliferation has led to numerous studies on the value of these methods for diagnosing different types of tumors and for clinical decision *** are no *** review discusses the use of several classical molecular proliferation markers,including Ki-67,proliferating cell nuclear antigen,cyclin D1 and DNA topoisomeraseⅡalpha,to characterize ameloblastomas and proposes the use of new proliferation markers used previously to characterize other *** use of these biomark-ers offers valuable opportunities to evaluate the biological behavior of this type of odontogenic tumor.
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