检索结果-南通市图书馆

Recurrence and cancerization of ameloblastoma: multivariate analysis of 87 recurrent craniofacial ameloblastoma to assess risk factors associated with early recurrence and secondary ameloblastic carcinoma

引用

Chinese Journal of Cancer Research 2017年第3期29卷 189-195页

作者： Rong Yang Zheqi Liu Sandhya Gokavarapu Canbang Peng Wei Cao Tong Ji Department of Oral and Maxillofacial-Head and Neck Oncology Shanghai Stomatology Key LaboratoryShanghai Ninth People's HospitalShanghai Jiao Tong University School of Medicine Head&Neck Oncology Reconstructive Surgery Department of Surgical OncologyKrishna Institute of Medical Science

Objective: The recurrence and progression of ameloblastoma are unpredictable. Therefore, we examined the influence of clinical factors on recurrence time and analyzed the clinical factors associated with early recurrence and cancerization. We then developed a staging system to predict early recurrence and cancerization. Methods: All of the primary craniofacial ameloblastoma patients treated in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine were recorded. There were 87 recurrent cases used to create a staging system and tested in a Cox regression analysis for risk factors associated with early recurrence or cancerization following surgery. Results: There were 890 craniofacial ameloblastoma patients, and 72 cases had recurrence. There were also 15 cases with cancerous recurrence. The overall recurrence rate was 9.78%, and the cancer rate was 1.69%. The primary cases were classified into the following 3 stages based on clinicopathological features: stage I, the maximum tumor diameter 6 cm or tumor invasion to the maxilla sinus/orbital floor/soft tissue; and stage III, tumor invasion of the skull base or metastasis into regional lymph nodes. When the method of surgery was controlled by partial correlation, the staging had significance with recurrence time (P=0.004). The Cox analysis showed the tumor stage was correlated with recurrence time (P=0.027) and cancerization time (P=0.002). However, the surgical method did not influence the recurrence time when adjusted for cofounding variables. Conclusions: Tumor larger than 6 cm and invasion to soft tissues or adjacent anatomical structures are associated with early recurrence. This staging system can be used to predict the risk factors of early recurrence and cancerization in ameloblastoma patients.

关键词： Recurrence ameloblastoma stage ameloblastic carcinoma cancerization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Contrast-enhanced multidetector computed tomography features and histogram analysis can differentiate ameloblastomas from central giant cell granulomas

引用

World Journal of Radiology 2022年第9期14卷 329-341页

作者： Adarsh Ghosh Meyyappan Lakshmanan Smita Manchanda Ashu Seith Bhalla Prem Kumar Ongkila Bhutia Asit Ranjan Mridha Department of Radiology Children's Hospital of PhiladelphiaPhiladelphiaPA 19104United States Department of Radiology All India Institute of Medical SciencesNew Delhi 110029India Department of Radiodiagnosis All India Institute of Medical SciencesNew Delhi 110029India Department of Oral&Maxillofacial Surgery All India Institute of Medical SciencesNew Delhi 110029India Department of Pathology All India Institute of Medical SciencesAnsari NagarNew Delhi 110029India

BACKGROUND No qualitative or quantitative analysis of contrast-enhanced computed tomography(CT)images has been reported for the differentiation between ameloblastomas and central giant cell granulomas(CGCGs).AIM To describe differentiating multidetector CT(MDCT)features in CGCGs and ameloblastomas and to compare differences in enhancement of these lesions qualitatively and using histogram analysis.METHODS MDCT of CGCGs and ameloblastomas was retrospectively reviewed to evaluate qualitative imaging descriptors.Histogram analysis was used to compare the extent of enhancement of the soft tissue.Fisher’s exact tests and Mann–Whitney U test were used for statistical analysis(Pameloblastomas were reviewed.ameloblastomas had a predilection for the posterior mandible with none of the CGCGs involving the angle.CGCGs were multilocular(58.3%),with a mixed lytic sclerotic appearance(75%).Soft tissue component was present in 91%of CGCGs,which showed hyperenhancement(compared to surrounding muscles)in 50%of cases,while the remaining showed isoenhancement.Matrix mineralization was present in 83.3%of cases.ameloblastomas presented as a unilocular(66.7%),lytic(60.6%)masses with solid components present in 81.8%of cases.However,the solid component showed isoenhancement in 63%.No matrix mineralization was present in 69.7%of cases.Quantitatively,the enhancement of soft tissue in CGCG was significantly higher than in ameloblastoma on histogram analysis(P49.05 HU in the tumour providing 100%sensitivity and 85%specificity in identifying a CGCG.CONCLUSION A multilocular,lytic sclerotic lesion with significant hyperenhancement in soft tissue,which spares the angle of the mandible and has matrix mineralization,should indicate prospective diagnosis of CGCG.

关键词： ameloblastoma Granuloma Giant cell Multidetector CT

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ameloblastoma—A Locally Destructive and Invasive Tumour—Review of Literature

引用

International Journal of Otolaryngology and Head & Neck Surgery 2014年第5期3卷 216-222页

作者： Mir Ruquaya Vikram Pratap Singh Sr. Consultant Surgical Oncology Indraprastha Apollo Hospital New Delhi India

The ameloblastoma is the second most common odontogenic tumour [1]. It occurs exclusively in the jaws, with a strong predilection for the posterior region of the mandible. Although benign, the ameloblastoma is a destructive tumour, locally invasive and presents a high rate of recurrence despite adequate surgical removal. A thorough understanding of its clinico-pathological behaviour is essential to avoid recurrence associated with inadequately treated disease. Currently wide resection and immediate reconstruction are the treatment of choice.

关键词： ameloblastoma Reconstruction Presentation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review

引用

World Journal of Clinical Oncology 2020年第1期11卷 31-42页

作者： Rogelio González-González Sandra López-Verdín Jesús Lavalle-Carrasco Nelly Molina-Frechero Mario Isiordia-Espinoza Ramón G Carreón-Burciaga Ronell Bologna-Molina Department of Research School of DentistryUniversidad Juárez del Estado de DurangoDurango 34000Mexico Research Institute of Dentistry Health Science CenterUniversidad de GuadalajaraGuadalajara 4430Mexico Department of Health Care Xochimilco UnitUniversidad Autónoma Metropolitana XochimilcoMéxico 04960Mexico Department of Clinics Biomedical Sciences DivisionCentro Universitario de los AltosUniversidad de GuadalajaraTepetitlán de Morelos 47620Mexico Molecular Pathology Area School of DentistryUniversidad de la RepúblicaMontevideo 11600Uruguay

BACKGROUND ameloblastomas are common benign epithelial odontogenic neoplasms that present an aggressive and unpredictable behavior that may modify treatment strategies.Different signaling pathways that participate in the progression of these tumors have been identified.B-raf proto-oncogene serine/threonine kinase(BRAF)is a protein involved in the behavior of ameloblastomas,and it is related to many cell mechanisms.BRAF gene mutations have been identified in ameloblastomas,of which the BRAF V600E(valine substituted by glutamic acid at amino acid 600)mutation has been the most common and can be present concomitantly with other mutations that may be involved in its behavior.Targeted therapies have been used as an alternative in the case of resistance or contraindications to conventional treatments.AIM To document the presence of BRAF V600E and additional mutations,their behavior,and targeted therapies in these tumors.METHODS An electronic literature search was conducted according to PRISMA guidelines in PubMed/MEDLINE,Cochrane,EMBASE,and SpringerLink using the terms“ameloblastomas”,“BRAF V600E”,“additional mutations”,and“targeted therapies”.ameloblastomas were classified according to WHO guidelines.Inclusion criteria were articles in English,published not more than 10 years ago,and studies with laboratory works related to BRAF V600E.Articles were evaluated by two independent reviewers and retrieved for full-text evaluation.The EBLIP Critical Appraisal Checklist was used to evaluate the quality of the eligible studies.Descriptive statistical analysis was performed.RESULTS Two independent reviewers,with a substantial concordance indicated by a kappa coefficient of k=0.76,evaluated a total of 19 articles that were included in this study.The analysis registered 521 conventional ameloblastomas(AM),81 unicystic ameloblastomas(UA),13 ameloblastic carcinomas(AC),three metastatic ameloblastomas(MA),and six peripheral ameloblastomas(PA),of which the histopathological type,anatomic location,laboratory tests,expression of BRAF

关键词： ameloblastoma B-raf proto-oncogene serine/threonine kinase B-raf protooncogene serine/threonine kinase V600E Additional mutations Targeted therapies

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Soft Tissue Recurrence with a Mucocele of an Intraosseous ameloblastoma

引用

Open Journal of Stomatology 2017年第8期7卷 336-344页

作者： Hiromitsu Yamamoto Ken-Ichiro Murakami Mariko Kawai Hitoshi Nagatsuka Kazuhisa Bessho Department of Oral and Maxillofacial Surgery Graduate School of Medicine Kyoto University Kyoto Japan Department of Oral and Maxillofacial Surgery Ako City Hospital Ako Japan Department of Pharmacology Osaka Dental University Osaka Japan Department of Oral Pathology and Medicine Graduate School of Medicine and Dentistry Okayama University Okayama Japan

ameloblastoma is an odontogenic tumor of high frequency and usually occurs as an intraosseous growth. ameloblastomas frequently recur, sometimes undergoing malignant transformation. These tumors are usually characterized as being multilocular, of the follicular type histopathologically, and invading strongly at the border region of the tumor. More than 10% p53-positive tumor cells give a prognostic indication for a tendency to recur. A recurrent ameloblastoma usually occurs in the intraosseous region near the site of the original lesion. In very rare cases, a recurrent tumor proliferates distantly from the original site in the soft tissue only. We report a rare case of recurrent ameloblastoma in the buccal mucosa with a mucocele that originated from the small salivary glands after the extirpation of an intraosseous (mandibular) ameloblastoma. We also performed a p53 immunohistochemical study of this recurrent tumor.

关键词： ameloblastoma Soft Tissue Recurrence Follicular Type Mucocele p53

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ki-67 immunohistochemical expression in mandibular ameloblastoma: A prognostic indicator for local recurrence

引用

Open Journal of Stomatology 2013年第9期3卷 520-526页

作者： Ayman Hegab Mohmmad Shuman Mohammed Abd El-Akher Delaram Arwlan Medcal City Teaching Hospital Teaching Laboratory Baghdad Iraq Oral and Maxillofacial Surgery Faculty of Dental Medicine Al-Azhar University Assuit Egypt Oral and Maxillofacial Surgery Faculty of Dental Medicine Al-Azhar University Cairo Egypt

Objective: This study used Ki-67 to evaluate the proliferative activity of ameloblastoma in an attempt to provide a scientific basis for any differences in the biologic behaviour that exists between the different types of ameloblastoma and correlate the results with the recurrence rate. Study design: We assessed Ki-67 expression by immunohistochemistry in 32 cases of mandibular ameloblastoma. Formalin-fixed, paraffinembedded blocks were sectioned and used for Haematoxylin & Eosin (H&E) staining. H&E slides were used to re-evaluate the histological types of the ameloblastoma. Immunohistochemical analysis for Ki-67 with a labelled streptavidin-biotin-peroxidase complex technique was performed on tumour sections using Monoclonal Mouse Anti-Human Ki-67 Antigen (clones MIB1, code M7240, Dako Corporation). Lymph nodes (lymphoma) were used as positive control for Ki-67. Results: The specimens comprised 18 cases of Follicular ameloblastoma, 7 cases of Cystic ameloblastoma, 4 cases of plexiform ameloblastoma, and 3 cases of Acanthotic ameloblastoma. The results showed that cellular proliferative activity varied within the ameloblastoma types. There was no statistically significant difference in the Ki-67 Acanthotic, cystic and follicular types of ameloblastoma, while plexiform type showed statistically significantly higher levels than the other 3 types. The mean Ki-67 labelling index of plexiform ameloblastoma ranged from 13 to 30 with a mean of 19.75. The mean values of Ki-67 were statistically significantly higher in recurrent than?non-recurrent cases. Conclusion: The significant expression of Ki-67 could provide useful prognostic markers for proliferative activity and good prognostic indicators for recurrence rate of mandibular ameloblastoma.

关键词： Mandibular ameloblastoma Recurrence Immunohistochemistry Ki-67

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hybrid ameloblastoma in a nigerian: Report of a case and review of literature

引用

Open Journal of Stomatology 2013年第7期3卷 347-353页

作者： O. A. Effiom O. James O. T. Akeju A. S. Salami O. Odukoya Department of Oral and Maxillofacial Surgery College of Medicine University of Lagos Lagos Nigeria Department of Oral Pathology and Oral Biology College of Medicine University of Lagos Lagos University Teaching Hospital Lagos Nigeria Department of Oral Pathology and Oral Biology Lagos University Teaching Hospital Lagos Nigeria

Background: Hybrid ameloblastoma is a rare type of ameloblastoma that is presently receiving attention in some quarters. Altogether, less than 30 cases have been reported in the scientific literature, thus calling for the need to report more cases in order to add to the body of knowledge on this lesion. This case report is aimed to add to the number of cases that are building up in the scientific literature. Materials and Methods: A 50-year-old female presented with a 3-year history of an anterior mandibular swelling extending from the body of the mandible on the right to the body of the mandible on the left. Orthopantomograph of the lesion revealed a mixed radiolucent and radiopaque lesion that extended from the distal region of the right mandibular second premolar to distal region of the left mandibular second molar. Segmental mandibulectomy with immediate replacement with reconstruction was undertaken. Results: Specimen which was subjected to histopathologic examination reported a diagnosis of Keratinizing Follicular ameloblastoma and Desmoplastic ameloblastoma with Osteoplasia, consistent with a diagnosis of Hybrid ameloblastoma. There has been no sign of recurrence 7 months after a regular follow-up and the patient is planned for a long term follow-up. Conclusion: Besides histological details that combine both conventional ameloblastoma and desmoplastic ameloblastoma, the present case of hybrid ameloblastoma bears similar clinical features as well as treatment modalities to that of conventional solid multicystic ameloblastoma.

关键词： ameloblastoma Hybrid Nigerian

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The sequential treatment of extensive mandibular ameloblastoma

引用

Case Reports in Clinical Medicine 2013年第8期2卷 484-489页

作者： Ruixiu Cheng Xingmao Fu Jianhui Ma Shuliang Li Jie Yu Kun Yan Yang Xue Department of Oral Biology School of Stomatology The Fourth Military Medical University Xi’an China Department of Stomatology The 89th Hospital of PLA Weifang China Institute of Traumatic Orthopedics The 89th Hospital of PLA Weifang China

ameloblastoma is the most frequent odontogenic tumor of the jaw. If not treated, ameloblastoma can gain an enormous size and cause severe facial disfigurement and functional impairment. Here we report two patients afflicted with extensive mandibular ameloblastoma (sized in 23 cm × 18 cm × 17 cm and 15 cm × 12 cm × 10 cm, respectively). Both the patients received the same sequential treatment including radical tumor resection, simultaneous reconstruction with fibula free flap graft, vertical distraction osteogenesis on the fibula graft, placement of endosseous dental implants, and final pros-thodontic rehabilitation. It took about 15 months to finish the entire course of treatment. And after the four-year follow-up, neither soft tissue related, nor hard tissue related problems were observed. Satisfactory facial symmetry, chewing and speech functions of the patients were restored. So this sequential treatment for extensive mandibular ameloblastoma can obtain an excellent effect by the shortest time and the lowest economical cost. Furthermore, the series also can be used to reconstruct giant mandibular defects caused by different reasons.

关键词： ameloblastoma Mandibular Defect Fibula Flap Sequential Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Desmoplastic ameloblastoma —A Case Report

引用

Open Journal of Stomatology 2017年第3期7卷 180-185页

作者： G. Gandhi A. Amirthagani Thanjavur Medical College and Hospital Thanjavur India

The desmoplastic ameloblastoma (DA) is a rare variant of the conventional ameloblastoma. It accounts for only 4% to 13% of all ameloblastomas. Desmoplastic ameloblastoma (DA) was included in the World Health Organization Classification of Head and Neck Tumors (WHO-2005) as a variant of ameloblastoma with specific clinical, imaging and histological features. The desmoplastic variant of ameloblastoma usually appears in the anterior and premolar regions as a mixed radiolucent and radiopaque lesion, sometimes resembling a benign fibro-osseous lesion [1]. ameloblastoma is a locally aggressive tumor that may cause recurrence and in rare cases, malignant transformation with repeated postsurgical recurrences [2] [3]. In this paper we present a case of a 47-year-old female with swelling in the left upper jaw, bopsy of which turned out to be desmoplastic ameloblastoma.

关键词： ameloblastoma Desmoplastic ameloblastoma Benign Fibro-Osseous Lesion Odontogenic Tumor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Large ameloblastoma of Mandible: Our Experience with Intermaxillary Fixation

引用

International Journal of Otolaryngology and Head & Neck Surgery 2016年第1期5卷 17-22页

作者： Anoop Attakkil Vandana Thorawade Rajesh Kar Shobhna Chandran Devkumar Rengaraja Karthik Rao Dnyaneshwar Rohe Department of ENT Grant Medical College & Sir J.J. Hospital Mumbai India

ameloblastomas are benign dental tumors, constituting 15% of oral neoplasms, most frequent odontogenic tumor of the jaw. Patient presenting at a late stage usually presents with large swelling with facial deformity. We present a case of 50 years old male who presented with recurrent ameloblastoma on the left side of the mandible causing facial disfigurement and functional impairment. Adequate removal of the tumor required hemimandibulectomy and intermaxillary fixation was done without any bony reconstruction. We would like to focus on the excellent postoperative result with regard to facial symmetry and functional improvement obtained in this case, though the available management protocols differ and are more advanced in current scenario. This case report gives hope and guidance to the surgeons who face difficulty in managing the deforming benign bony tumors due to the unavailability of facility and funds to reconstruct.

关键词： ameloblastoma Resection Intermaxillary Fixation Mandible

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：