Form confers function:Case of the 3'X region of the hepatitis C virus genome

作     者：Mariola Dutkiewicz Jerzy Ciesiolka 

作者机构：Institute of Bioorganic ChemistryPolish Academy of SciencesPoznan 61-704Poland 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2018年第24卷第30期

页      面：3374-3383页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：Supported by the Polish Ministry of Science and Higher Education under the KNOW program and Foundation for Polish Science No.POMOST/2013-8/5 

主　　题：Hepatitis C virus 3’UTR 3’X-tail 3’X region 3’X RNA RNA structure 

摘      要：At the 3 end of genomic hepatitis C virus(HCV) RNA there is a highly conserved untranslated region,the 3 X-tail,which forms part of the 3 *** region plays key functions in regulation of critical processes of the viral life *** 3 X region is essential for viral replication and *** is also responsible for regulation of switching between translation and transcription of the viral *** is some evidence indicating the contribution of the 3 X region to the translation efficiency of the viral polyprotein and to the encapsidation *** different secondary structure models of the 3 X region,based on computer predictions and experimental structure probing,have been *** is likely that the 3 X region adopts more than one structural form in infected cells and that a specific equilibrium between the various forms regulates several aspects of the viral life *** most intriguing explanations of the structural heterogeneity problem of the 3 X region came with the discovery of its involvement in long-range RNA-RNA interactions and the potential for homodimer *** article summarizes current knowledge on the structure and function of the 3 X region of hepatitis C genomic RNA,reviews previous opinions,presents new hypotheses and summarizes the questions that still remain unanswered.