Complements are involved in alcoholic fatty liver disease, hepatitis and fibrosis
Complements are involved in alcoholic fatty liver disease, hepatitis and fibrosis作者机构：Department of Hepatopancreatobiliary Surgery the first Affiliated Hospital of Guangxi Medical University
出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)
年 卷 期：2018年第10卷第10期
页 面：662-669页
基 金：Supported by State Key Program of National Natural Science Foundation of China,No.8143000311 National Natural Science Foundation of China,No.81660103 and No.81771674 111 Project,No.D17011 Guangxi BaGui Scholars the Natural Science Foundation of Guangxi Province,No.2015GXNSFFA139004
主 题：Alcoholic liver disease complement system proteins Complement regulator liver cells hepatocyte injury
摘 要：The complement system is a key component of the body s immune system. When abnormally activated, this system can induce inflammation and damage to normal tissues and participate in the development and progression of a variety of diseases. In the past, many scholars believed that alcoholic liver disease(ALD) is induced by the stress of ethanol on liver cells, including oxidative stress and dysfunction of mitochondria and protease bodies, causing hepatocyte injury and apoptosis. Recent studies have shown that complement activation is also involved in the genesis and development of ALD. This review focuses on the roles of complement activation in ALD and of therapeutic intervention in complement-activation pathways. We intend to provide new ideas on the diagnosis and treatment of ALD.
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