Innate and adaptive immune responses against picornaviruses and their counteractions: An overview

作     者：Andreas Dotzauer Leena Kraemer 

作者机构：Department of VirologyUniversity of Bremen 28359 Bremen Germany 

出 版 物：《World Journal of Virology》 (世界病毒学杂志)

年 卷 期：2012年第1卷第3期

页      面：91-107页

学科分类：10[医学] 

基　　金：Supported by The Tonjes-Vagt-Stiftung Bremen Germany 

主　　题：Picornaviruses and infection Poliovirus Coxsackievirus Human rhinovirus Hepatitis A virus Adaptive immune system Innate immune system Antibody response and inflammation Apoptosis Interferon and cytokines 

摘      要：Picornaviruses, small positive-stranded RNA viruses, cause a wide range of diseases which is based on their differential tissue and cell type tropisms. This diversity is reflected by the immune responses, both innate and adaptive, induced after infection, and the subsequent interactions of the viruses with the immune system. The defense mechanisms of the host and the countermeasures of the virus significantly contribute to the pathogenesis of the infections. Important human pathogens are poliovirus, coxsackievirus, human rhinovirus and hepatitis A virus. These viruses are the beststudied members of the family, and in this review we want to present the major aspects of the reciprocal effects between the immune system and these viruses.