The Metabolic Basis of Tumor Growth and Metastasis
The Metabolic Basis of Tumor Growth and Metastasis作者机构：Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin’s Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin 300060 China
出 版 物：《Journal of Nutritional Oncology》 (肿瘤营养学杂志（英文）)
年 卷 期：2017年第2卷第1期
页 面：22-27页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：grants from the National Natural Science Foundation of China(81372394,81602158,81602156,and 81572321) Tianjin Health and Family Planning Commission Foundation of Science and Technology (15KG142).This workwas also supported by CSCO-Merck Serono Oncology Research Fund(Y-MX2015-092) Tianjin Science Foundation (No.15JCYBJC28200).The funders had no role in study design in collection,analysis,and interpretation of data in the writing of the report in the decision to submit this article for publication
主 题：Tumor Growth Metastasis Metabolism Adaptation
摘 要：Increasing research suggests that cancer is a metabolic *** tumor development,cancer cells increase their biosynthetic and bioenergetic demands to maintain tumor cell proliferation and *** focus of research on this topic has been on the metabolism of the primary tumor,while metabolic adjustments during primary tumor growth/progression and metastatic processes have not been extensively *** current evidence indicates that the metabolism during tumor development is ***,emerging data suggest that,once the tumor cells leave their primary sites,they may show different metabolic features distinct from the primary tumor,enabling them to successfully survive and *** this review,we summarize how this metabolic flexibility occurs during the growth of the primary tumor and the metastatic process,and also explore how metabolic adaptation is influenced by the microenvironments of the tumor *** hope that this review will provide inspiration and guidance for future research on tumor metabolism.
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