Redox-responsive ferrocene-containing poly(ionic liquid)s for antibacterial applications

作     者：Tikai Zhang Jiangna Guo Yingying Ding Hailei Mao Feng Yan 

作者机构：Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and EngineeringCollege of Chemistry Chemical Engineering and Materials Science Soochow University Department of Anesthesiology and Critical Care Medicine Zhongshan Hospital Fudan University 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2019年第62卷第1期

页      面：95-104页

核心收录：

学科分类：07[理学] 0703[理学-化学] 

基　　金：supported by the National Science Foundation for Distinguished Young Scholars(21425417) the National Natural Science Foundation of China(21704071) the Jiangsu Province Science Foundation for Youth(BK20170332) General Program Foundation of Jiangsu Province University Science Research Project(17KJB150033) General Program Foundation of Shanghai Municipal Commission of Health and Family Planning(201740107) the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions Science and Technology Innovation Fund Project of Zhongshan Hospital,Fudan University(2017ZSCX03) 

主　　题：antibacterial activities imidazolium cations ferrocene poly(ionic liquid) cytotoxicity 

摘      要：Ferrocene(Fc)-containing imidazolium type ionic liquids(ILs) and corresponding poly(ionic liquid)(PIL) membranes with tunable antibacterial activity based on electrochemical redox reaction and host-guest chemistry were developed. The effect of Fc moiety on the antimicrobial activities against both Staphylococcus aureus(S. aureus) and Escherichia coli(E. coli) was studied by minimum inhibitory concentration(MIC). The presence of Fc groups highly enhanced the antibacterial efficiency of Fccontaining ILs because of the generation of reactive oxygen species(ROS). The electrochemical oxidation of Fc to Fc+and the formation of inclusion complexes between Fc and β-CD via host-guest interactions decreased the antibacterial activities of ILs and PIL membranes. The antibacterial activities may be recovered in some extent upon the electrochemical reduction of Fc+to Fc or the exclusion of the Fc out of the cavity of β-CD. Furthermore, all the Fc-containing PIL membranes showed relatively low hemolysis activities and none cytotoxicity toward human cells, indicating clinical feasibility in topical applications.