Synthesis of Fragment Derivatives of Delta Sleep-inducing Peptide （1-4） Catalyzed by Enzymes in Organic Solvents

作     者：沈鸿雁 田桂玲 洪毅颖 李恒 叶蕴华 

作者机构：KeyLaboratoryofBioorganicChemistryandMolecularEngineeringMinistryofEducationCollegeofChemistryandMolecularEngineeringPekingUniversityBeifing100871China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2005年第23卷第5期

页      面：640-642页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the National Natural Science Foundation of China (20372008) 

主　　题：DSIP enzymatic synthesis organic solvent peptide 

摘      要：Synthesis of two fragment derivatives of delta sleep-inducing peptide (DSIP) (1-4), Boc-Trp-Ala-Gly-GlyNH-NHPh (1) and Boc-Trp-Ala-Gly-GlyOEt (2), catalyzed by proteases via 2+2 or 1+3 synthetic routes with different protecting groups at C-terminal in organic solvents was reported. The yield of N-Boc tetrapeptide with phenylhy-drazinyl protecting carboxyl group at C-terminal (1) was higher than that of N-Boc tetrapeptide ethyl ester (2) by2+2 route. The factors influencing the synthetic yield of the fragments of DSIP (1-4) were discussed.