Fabrication of Porous Mg-Zn Scaffold through Modified Replica Method for Bone Tissue Engineering

作     者：Amir Hamed Aghajanian Bijan Abbasi Khazaei Mohammad Khodaei Mohammad Rafienia 

作者机构：Department of Materials Engineering Faculty of Engineering Razi University Kermanshah Iran Dental Research Center School of Dentistry Isfahan University of Medical Sciences Isfahan 81746-73461 Iran Biosensor Research Center lsfahan University of Medical Sciences Isfahan 81744176 Iran 

出 版 物：《Journal of Bionic Engineering》 (仿生工程学报（英文版）)

年 卷 期：2018年第15卷第5期

页      面：907-913页

核心收录：

学科分类：081901[工学-采矿工程] 0819[工学-矿业工程] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：Isfahan University of Medical Sciences  IUMS 

主　　题：porous magnesium scaffold replica method Mg-Zn powder to water ratio mechanical properties 

摘      要：Biodegradable scaffolds are essential parts in hard tissue engineering. A highly porous magnesium-zinc （Mg-Zn 4 wt.%） scaffold with different Mg-Zn powder to liquid media ratios （50 wt.%, 70 wt.% and 90 wt.%） and different concentrations of ethanol （0 vol.%, 10 vol.%, 20 vol.% and 40 vol.%） were prepared through modified replica method. The mechanical properties were assessed through compression test and the structures of scaffolds were examined by Scanning Electron Microscope （SEM）. Results show that, the increase in Mg-Zn powder to liquid media ratio （50 wt.% to 90 wt.%） in ethanol free slurry, increases the thickness of struts （37 lam to 74 lam） and the plateau stress （0.5 MPa to 1.4 MPa）. The results obtained from X-ray Diffractometry （XRD） and compression test indicate that consuming ethanol in liquid media of replica, results in higher plateau stress by 46% due to less Mg-water reaction and no formation of Mg（OH）2 in the scaffold. The results of porosity measurement indicate that water-ethanol mixture composition and different solid fractions have no significant effects on true and apparent porosities of the fabricated scaffolds.