G protein-coupled receptors in energy homeostasis

作     者：WANG Jue XIAO RuiPing 

作者机构：Institute of Molecular MedicinePeking University 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2014年第57卷第7期

页      面：672-680页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 080702[工学-热能工程] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0807[工学-动力工程及工程热物理] 

主　　题：G-protein coupled receptor energy homeostasis metabolism 

摘      要：G-protein coupled receptors(GPCRs)compromise the largest membrane protein superfamily which play vital roles in physiological and pathophysiological processes including energy ***,they also represent the up-to-date most successful drug *** gut hormone GPCRs,such as glucagon receptor and GLP-1 receptor,have been intensively studied for their roles in metabolism and respective drugs have developed for the treatment of metabolic diseases such as type 2 diabetes(T2D).Along with the advances of biomedical research,more GPCRs have been found to play important roles in the regulation of energy homeostasis from nutrient sensing,appetite control to glucose and fatty acid metabolism with various *** investigation of their biological functions will not only improve our understanding of how our body keeps the balance of energy intake and expenditure,but also highlight the possible drug targets for the treatment of metabolic *** present review summarizes GPCRs involved in the energy control with special emphasis on their pathophysiological roles in metabolic diseases and hopefully triggers more intensive and systematic investigations in the field so that a comprehensive network control of energy homeostasis will be revealed,and better drugs will be developed in the foreseeable future.