The Hemodynamic Comparative Study Between Pulsatile and Non-Pulsatile VA ECMO:A Primary Numerical Study

作     者：Qi Zhang Bin Gao Yue Shi Chang Yu 

作者机构：School of Life Science and BioEngineeringBeijing University of TechnologyBeijing100124China. 

出 版 物：《Computer Modeling in Engineering & Sciences》 (工程与科学中的计算机建模（英文）)

年 卷 期：2018年第116卷第8期

页      面：247-262页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This study was partly funded by the National Natural Science Foundation of China(Grant No.11602007,91430215,11572014) BJUT Foundation Fund(Grant No.015000514316007) Key research and development program(2016YFC0103201,2017YFC0111104) New Talent(015000514118002) 

主　　题：pulsatile non-pulsatile VA ECMO hemodynamics CFD 

摘      要：Although pulsatile ECMO,as novel kinds of ECMO,has been attracted more and more attention,the differences of the hemodynamic effects of the pulsatile ECMO on the aorta,the cerebral perfusion,and left ventricular work were still *** aim of this study was to clarify the hemodynamic differences of the cardiovascular system between the pulsatile and non-pulsatile VA *** this study,three ECMO support modes,named as“constant flow mode,“co-pulse modeand“counter pulse mode,were *** computational fluid dynamics(CFD)study was carried *** distribution of the oxygenated blood,the blood velocity vector,the oscillatory shear index(OSI),the relative residence time(RRT),the left ventricular external work(EW),the equivalent left ventricular afterload(EAL)and the energy loss of cardiovascular system(EL)were calculated to compare the hemodynamic *** simulation results demonstrate that the oxygenated blood under co-pulse mode was easier to perfuse into the three braches vessels than that under both other *** addition,the ECMO under counter pulse mode could also achieve lowest RRT(constant flow mode 220 ***-pulse mode 132 *** pulse mode 93).Similarly,the ECMO under counter pulse mode could significantly reduce the left ventricular external work(co-pulse mode 1.51 w *** flow mode 1.44 w and counter pulse mode 1.30 w),left ventricular afterload(constant flow mode 1.03 mmHg·s/ml ***-pulse mode 1.67 mmHg·s/ml *** pulse mode 0.82 mmHg·s/ml)and energy loss of arterial system(constant flow mode 0.18 w ***-pulse mode 0.50 w *** pulse mode 0.16 w).In short,the ECMO under counter pulse mode could have advantages to the left ventricular *** contrast,the ECMO under co-pulse mode has more benefit to cerebral oxygen perfusion.