Effects of ulinastatin combined with hemoperfusion on renal function, fibrosis indexes and oxidative stress indexes of patients with paraquat poisoning

作     者：Rong-Xia Li 

作者机构：Emergency DepartmentQinghai Provincial People's HospitalXiningQinghai Province810007 

出 版 物：《Journal of Hainan Medical University》 (海南医学院学报（英文版）)

年 卷 期：2018年第24卷第12期

页      面：20-24页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Research Projects of Qinghai Provincial Health & Family Planning Commission No. 2017-wjx-14 

主　　题：Paraquat poisoning Ulinastatin Renal function Pulmonary fibrosis Oxidative stress response 

摘      要：Objective: To study the effects of ulinastatin combined with hemoperfusion on renal function, fibrosis indexes and oxidative stress indexes of patients with paraquat poisoning. Methods:Patients with paraquat poisoning who were treated in Qinghai Provincial People s Hospital between March 2014 and May 2017 were chosen as the research subjects, treated with hemoperfusion and divided into ulinastatin group and control group according to the use of ulinastatin or not in history data. The renal function markers, fibrosis indexes and oxidative stress indexes were measured before treatment and 1 week after treatment. Results: Compared with those of same group before treatment, serum Scr, BUN, Cys-C, β2-MG, TGF-β1, ICAM-1, MMP9, PICP, C-IV and MDA levels as well as peripheral blood Nrf2 and HO-1 expression intensity significantly decreased whereas serum CAT and SOD levels significantly increased after treatment, and serum Scr, BUN, Cys-C, β2-MG, TGF-β1, ICAM-1, MMP9, PICP, C-IV and MDA levels as well as peripheral blood Nrf2 and HO-1 expression intensity of ulinastatin group after treatment were significantly lower than those of control group whereas serum CAT and SOD levels were significantly higher than those of control group. Conclusion:Ulinastatin combined with hemoperfusion can improve the renal function, pulmonary fibrosis and oxidative stress in patients with paraquat poisoning.