A Numerical Study of Passive Receptor-Mediated Endocytosis of Nanoparticles:The Effect of Mechanical Properties
作者机构：Key Laboratory of Hydrodynamics(Ministry of Education)Department of Engineering MechanicSchool of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China. Department of Mathematics and StatisticsYork UniversityTorontoOntarioM3J1P3Canada.
出 版 物：《Computer Modeling in Engineering & Sciences》 (工程与科学中的计算机建模（英文）)
年 卷 期：2018年第116卷第8期
页 面：281-300页
核心收录：
学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学]
基 金：This work was supported by the National Natural Science Foundations of China(11372191,11232010) the Natural Science and Engineering Research Council of Canada
主 题：Receptor-mediated endocytosis nanoparticle uptake optimization method receptor-ligand bonds drug delivery
摘 要：In this work,a three-dimensional axisymmetric model with nanoparticle,receptor-ligand bonds and cell membrane as a system was used to study the quasi-static receptor-mediated endocytosis process of spherical nanoparticles in drug *** minimization of the system energy function was carried out numerically,and the deformations of nanoparticle,receptor-ligand bonds and cell membrane were *** show that passive endocytosis may fail due to the rupture of receptor-ligand bonds during the wrapping process,and the size and rigidity of nanoparticles affect the total deformation energy and the terminal wrapping *** results suggest that,in addition to the energy requirement,the success of passive endocytosis also depends on the maximum strength of the receptor-ligand bonds.
维普期刊数据库