1日龄新生儿出现早期先天性梅毒和多形红斑样大疱性靶形皮损:应用巢式PCR检测靶形斑块处苍白螺旋体基因组DNA
Early congenital syphilis and erythema multiformelike bullous targetoid lesions in a 1-day-old newborn: Detection of Treponema pallidum genomic DNA from the targetoid plaque using nested polymerase chain reaction出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)
年 卷 期：2006年第2卷第11期
页 面：7-8页
学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学]
主 题：苍白螺旋体 先天性梅毒 多形红斑 大疱 DNA 角化不良细胞 密螺旋体 血清学 呼吸窘迫 皮损组织病
摘 要：A 1-day-old male newborn was born with respiratory distress, low birth weight, hepatosplenomegaly, and bullous targetoid skin lesions over the face, back, buttocks, and extremities. A diagnosis of early congenital syphilis was made based on a treponemal serologic test. Pathologic examination of the skin lesion showed scattered dyskeratotic cells in the epidermis and interface dermatitis consistent with erythema multiforme. No spirochete could be found in the skin sections staining with Warthin-Starry stain. Using nested polymerase chain reaction, treponemal genomic DNA fragments encoding DNA polymerase I were detected.
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