Construction of the Skeleton of Phthalascidin, Mechanism of the Formation of the Key Tricyclic Lactam Intermediate

作     者：Zhan Zhu LIU Ye WANG Shi Zhi CHEN 

作者机构：Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050 

出 版 物：《Chinese Chemical Letters》 (中国化学快报(英文版))

年 卷 期：2002年第13卷第8期

页      面：701-704页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：Lactam phthalascidin mechanism Et-743. 

摘      要：The mechanism of the formation of a key tricyclic lactam intermediate 3 was studied. It was found that the E-form compound 3 was transformed from the Z-form compound 4. The formation of 4 was a kinetically controlled process while the formation of 3 was a thermodynamically favorable one. A possible mechanism was given in this paper.