PillCamESO食管胶囊内镜和传统上消化道内镜在诊断慢性胃食管反流病患者准确性的前瞻性研究

作     者：Eliakim R. Sharma V.K. Yassin K. 郑世成 

作者机构：Division of Gastroenterology Mayo Clinic Scottsdale 13400 E. Shea Boulevard Scottsdale AZ 85259 United States Dr. 

出 版 物：《世界核心医学期刊文摘（胃肠病学分册）》 (Core Journals in Gastroenterology)

年 卷 期：2006年第2卷第1期

页      面：43-43页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：胃食管反流 PillCamESO 胶囊内镜 食管疾病 上消化道内镜 可视化检查 Barrett 食管 

摘      要：Introduction: Endoscopy is commonly performed to evaluate for suspected or established esophageal diseases including gastroesophageal reflux disease (GERD) and its complications. The newly developed PillCam ESO Esophageal Capsule offers an alternative approach to visualize the esophagus and to evaluate patients with suspected esophageal disease. Aim: Compare the accuracy (specifi-city, sensitivity, positive predictive value [PPV], and negative predictive value [NPV]) of esophageal capsule endoscopy (ECE) compared with esophagogastroduodenoscopy (EGD) in evaluating patients with GERD. Methods: A multicenter pivotal trial was conducted at seven sites. The PillCam ESO esophageal capsule is similar to the standard capsule endoscope used for the small bowel but acquires video images from both ends of the device at 2 frames/second/end. A total of 106 patients (93 GERD; 13 Barrett) underwent ECE followed by EGD. ECE videos were evaluated by an investigator blinded to EGD findings. A blinded adjudication committee reviewed all discrepant findings between ECE and EGD. Results: Sixty-six of 106 patients had positive esophageal findings, ECE identified esophageal abnormalities in 61 (sensitivity, 92% ; specificity, 95% ). The per-protocol sensitivity, specificity, PPV, and NPV of ECE for Barrett esophagus were 97% , 99% , 97% , and 99% , respectively, and for esophagitis 89% , 99% , 97% , and 94% , respectively. ECE was preferred over EGD by all patients. There were no adverse events related to ECE. Conclusions: ECE is a convenient and sensitive method for visualization of esophageal mucosal pathology and may provide an effective method to evaluate patients for esophageal disease.