Genomic instability and cancer:an introduction
基因组不稳定和癌症:介绍作者机构:The Cancer Institute of New Jerseyand Department of Radiation OncologyRobert Wood Johnson Medical SchoolUniversity of Medicine and Dentistry of New Jersey195 Little Albany StreetNew BrunswickNJ 08903USA
出 版 物:《分子细胞生物学报:英文版》 (Journal of Molecular Cell Biology)
年 卷 期:2011年第3卷第1期
页 面:1-3页
核心收录:
学科分类:0710[理学-生物学] 0831[工学-生物医学工程(可授工学、理学、医学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学]
基 金:National Cancer Institute NCI (R01CA156706)
主 题:alterations damage precise
摘 要:Genomic instability refers to an increased tendency of alterations in the genome during the life cycle of *** is a major driving force for *** a cell division,genomic instability is minimized by four major mechanisms:high-fidelity DNA replication in S-phase,precise chromosome segregation in mitosis,error free repair of sporadic DNA damage,and a coordinated cell cycle *** introduction summarizes the major molecular processes that contribute to these mechanisms in the context of prevention of genomic instability and tumorigenesis.