Genomic instability and cancer:an introduction

作     者：Zhiyuan Shen 

作者机构：The Cancer Institute of New Jerseyand Department of Radiation OncologyRobert Wood Johnson Medical SchoolUniversity of Medicine and Dentistry of New Jersey195 Little Albany StreetNew BrunswickNJ 08903USA 

出 版 物：《分子细胞生物学报:英文版》 (Journal of Molecular Cell Biology)

年 卷 期：2011年第3卷第1期

页      面：1-3页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：National Cancer Institute  NCI  (R01CA156706) 

主　　题：alterations damage precise 

摘      要：Genomic instability refers to an increased tendency of alterations in the genome during the life cycle of *** is a major driving force for *** a cell division,genomic instability is minimized by four major mechanisms:high-fidelity DNA replication in S-phase,precise chromosome segregation in mitosis,error free repair of sporadic DNA damage,and a coordinated cell cycle *** introduction summarizes the major molecular processes that contribute to these mechanisms in the context of prevention of genomic instability and tumorigenesis.