Determining the critical size of a rabbit rib segmental bone defect model
作者机构：Liaocheng People’s HospitalMedical College of Liaocheng UniversityLiaocheng 252000P.R.China Tsinghua UniversityBeijing 100084P.R.China
出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)
年 卷 期：2016年第3卷第5期
页 面：323-328页
核心收录：
学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学]
基 金：This study is in part supported by Science Foundation of Shandong Province of China(ZR2015EL002) National Natural Science Foundation of China(51572144)
主 题：animal test bone critical size defect rib defect periosteum
摘 要：In order to establish and standardize the rabbit rib segmental bone defect model,it is of vital importance to determine rabbit rib critical size defect(CSD).According to the general time needed for spontaneous long-bone regeneration,three-month observation period was set to determine the *** rabbit rib segmental bone defects with different sizes from 1 to 5cm with or without periosteum were performed in the eighth rib of 4-month-old male New Zealand rabbits and underwent Xray examinations at the 4th,8th and 12th weeks *** gross and histological examinations at postoperative week 12 were evaluated,which showed that the critical sizes in the rabbit rib models with and without periosteum were 5 and 2 cm,*** study provides prerequisite data for establishing rabbit rib CSD model and evaluating bonematerials using this model.
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