Design of SERS nanoprobes for Raman imaging:materials, critical factors and architectures

作     者：Mingwang Li Yuanyuan Qiu Chenchen Fan Kai Cui Yongming Zhang Zeyu Xiao 

作者机构：Department of Pharmacology and Chemical Biology Institute of Medical Sciences Shanghai Jiao Tong University School of Medicine Translational Medicine Collaborative Innovation Center Shanghai Jiao Tong University School of Medicine Collaborative Innovation Center of Systems Biomedicine Shanghai Jiao Tong University School of Medicine 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2018年第8卷第3期

页      面：381-389页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 070205[理学-凝聚态物理] 070302[理学-分析化学] 0703[理学-化学] 0702[理学-物理学] 

基　　金：the National Natural Science Foundation of China(Nos.81471779 and 31671003) Thousand Young Talents Program,the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning(No.TP2014028)for their financial support 

主　　题：Raman imaging Surface-enhanced Raman scattering Nanoprobes Architecture Biomedical application Enhancement factors Nanoparticles 

摘      要：Raman imaging yields high specificity and sensitivity when compared to other imaging modalities, mainly due to its fingerprint signature. However, intrinsic Raman signals are weak, thus limiting medical applications of Raman imaging. By adsorbing Raman molecules onto specific nanostructures such as noble metals, Raman signals can be significantly enhanced, termed surfaceenhanced Raman scattering(SERS). Recent years have witnessed great interest in the development of SERS nanoprobes for Raman imaging. Rationally designed SERS nanoprobes have greatly enhanced Raman signals by several orders of magnitude, thus showing great potential for biomedical applications.In this review we elaborate on recent progress in design strategies with emphasis on material properties,modifying factors, and structural parameters.