The BK channel:a vital link between cellular calcium and electrical signaling

作     者：Brad S.Rothberg 

作者机构：Department of BiochemistryTemple University School of MedicinePhiladelphiaPA 19140USA 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2012年第3卷第12期

页      面：883-892页

核心收录：

学科分类：080903[工学-微电子学与固体电子学] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：supported in part by the National Institute of General Medical Science of the National Institutes of Health(Grant No.R01GM068523) 

主　　题：RCK domain voltage sensor blood pressure leucine-rich repeat-containing(LRRC)protein 

摘      要：Large-conductance Ca^(2+)-activated K+channels(BK channels)constitute an key physiological link between cellular Ca^(2+) signaling and electrical signaling at the plasma *** these channels are critical to the control of action potential firing and neurotrans-mitter release in several types of neurons,as well as the dynamic control of smooth muscle tone in resis-tance arteries,airway,and *** advances in our understanding of K^(+) channel structure and function have led to new insight toward the molecular mecha-nisms of opening and closing(gating)of these *** we will focus on mechanisms of BK channel gating by Ca^(2+),transmembrane voltage,and auxiliary subunit proteins.