Neuroprotective effects of stearic acid against toxicity of oxygen/glucose deprivation or glutamate on rat cortical or hippocampal slices
Neuroprotective effects of stearic acid against toxicity of oxygen/glucose deprivation or glutamate on rat cortical or hippocampal slices作者机构：School of Pharmacy Shanghai Jiaotong University Shanghai China
出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))
年 卷 期：2006年第27卷第2期
页 面：145-150页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
基 金：Project supported by the Natural Science Foundation of Shanghai(№03ZR14056)
主 题：fatty acid brain slices ischemia glutamate energy metabolism
摘 要：Aim:To observe the effects of stearic acid,a long-chain saturated fatty acidconsisting of 18 carbon atoms,on brain(cortical or hippocampal)slices insultedby oxygen-glucose deprivation(OGD),glutamate or sodium azide(NAN3)in ***:The activities of hippocampal slices were monitored by population spikesrecorded in the CA1 region,In vitro injury models of brain slice were induced by10min of OGD,1 mmol/L glutamate or 10 mmol/L *** 30min of pre-incubation with stearic acid(3-30μmol/L),brain slices(cortical or hippocampal)were subjected to OGD,glutamate or NaN3,and the tissue activities were evalu-ated by using the 2,3,5-triphenyltetrazolium chloride ***886 [5 mmol/L;a noncompetitive inhibitor of proliferator-activated receptor(PPAR-α)] or BADGE(bisphenol A diglycidyl ether;100μmol/L;an antagonist of PPAR-γ)were testedfor their effects on the neuroprotection afforded by stearic ***:Viabilityof brain slices was not changed significantly after direct incubation with ***,glutamate and NaN3injury significantly decreased the viability ofbrain *** acid(3-30 μmol/L)dose-dependently protected brain slicesfrom OGD and glutamate injury but not from NaN3injury,and its neuroprotectiveeffect was completely abolished by ***:Stearic acid can protectbrain slices(cortical or hippocampal)against injury induced by OGD or *** neuroprotective effect may be mainly mediated by the activation of PPAR-γ.
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