首次使用长效醋酸甲羟孕酮患者2年中骨密度的改变

作     者：Clark M.K Sowers M.R Nichols S Levy B. 王雅楠 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2005年第1卷第5期

页      面：31-32页

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：骨密度 激素避孕 纵向变化 双能 学术研究机构 特征性变化 纵向研究 体育活动 钙摄入量 负相关 

摘      要：To compare longitudinal changes in bone mineral density (BMD) among first-tim e depot medroxyprogesterone acetate (DMPA) users to women using no hormonal cont raception, and evaluate user characteristics associated with that BMD change. Pr ospective longitudinal study. Healthy volunteers in an academic research environ ment. Women, aged 18 to 35, choosing DMPA for contraception (n = 178) and women using no hormonal contraception (n = 145). Hip and spine BMD measured, at three -month intervals for 24 months, by dual energy x-ray absorptiometry. Mean hip BMD declined 2.8%(SE = 0.034) 12 months following DMPA initiation and 5.8%(SE = 0.096) after 24 months. Mea n spine (L1-L3) BMD declined 3.5%(SE = 0.022) and 5.7%(SE = 0.034), respectiv ely, after one and two years of DMPA use. Mean hip and spine BMD of control part icipants changed less than 0.9%over the same period. Among DMPA users, body mas s index (BMI) change was inversely associated with BMD change at the hip, but no t at the spine. Calcium intake, physical activity, and smoking did not influence BMD change in either group. Hip and spine BMD declined after one DMPA injection and this decline continued with each subsequent injection for 24 months. With t he exception of increasing BMI among DMPA users, no user characteristics offered protection against DMPA-related BMD loss.