Rational design and biomedical applications of DNA-functionalized upconversion nanoparticles

作     者：Xinwen Liu Meng Liu Jiajia Chen Zhihao Li Quan Yuan 

作者机构：Key laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education) College of Chemistry and Molecular Sciences Wuhan University 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2018年第29卷第9期

页      面：1321-1332页

核心收录：

学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 0702[理学-物理学] 

基　　金：supported by the National Key R&D Program of China(No.2017YFA0208000) the National Natural Science Foundation of China(Nos.21422105,21675120) the Natural Science Foundation of Hubei Province(No.2015CFA032) Ten Thousand Talents Program for Young Talents 

主　　题：Lanthanide-doped upconversion nanoparticles DNA Biosensor Bioimaging Disease therapy 

摘      要：Lanthanide-doped upconversion nanoparticles （UCNPs） offer unique advantages in term of low autofluorescence, high signal-to-noise ratio and deep tissue penetration, and have attracted considerable attention in biomedical applications. DNA, beyond the properties of self-assembly, also exhibits multiple functions such as molecular recognition, drug loading capacity and therapeutic effect. In this regard, the combination of UCNPs and DNA offers a promising and powerful platform for potential applications in biosensing, bioimaging and disease therapy. In this review, we mainly introduce recent progresses of DNA-functionalized upconversion materials, providing an overview of the design and applications in biosensing, bioimaging and therapy. The challenges and future perspectives are also discussed, aiming to promote their applications in material science and biomedicine.