Gene expression of hepatocyte growth factor and its receptor in HCC and nontumorous liver tissues
Gene expression of hepatocyte growth factor and its receptor in HCC and nontumorous liver tissues出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：1999年第5卷第2期
页 面：31-33页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 071008[理学-发育生物学]
主 题：liver neoplasm hepatocyte growth factor receptor, hepatocyte growth factor gene expression
摘 要：AIM To study the changes of gene expression of hepatocyte growth factor (HGF) and hepatocyte growth factor receptor (HGFr) in hepatocellular carcinoma (HCC) tissue and nontumorous liver tissue and the relationship between these changes and the biological behavior of the *** Gene expression of HGF and HGFr in 26 cases of HCC tissue and their adjacent nontumorous liver tissues was determined with digoxigenin-labeled DNA *** Positive expression of HGF in HCC tissue was similar to that in the adjacent nontumorous liver tissue, but positive rate of HGF expression was lower than HGFr gene expression. However, HGFr expression was higher in the metastatic cases than in those without metastasis. It was found that HGFr was overexpressed in HCC tissue as well as in the adjacent nontumorous liver *** There seems to be a close relationship between overexpression of HGFr gene and tumor metastasis, and the HGF and HGFr system plays an important role in regulating tumor growth and metastasis.
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