Activities of the Deriviatives of Chitin on the Osbeoblast Proliferation and the Effect on Bone Strength in Ovariectomized Rats

作     者：WEI Changzheng LIU Wanshun HAN Baoqin DUAN Yixiang 

作者机构：College of Marine Life Sciences Ocean University of China Qingdao 266003 Shandong China Orthopaedics of Qingdao Municipal Hospilal Qingdao 266003 Shandong China 

出 版 物：《Wuhan University Journal of Natural Sciences》 (武汉大学学报（自然科学英文版）)

年 卷 期：2006年第11卷第3期

页      面：715-719页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0836[工学-生物工程] 

基　　金：Supported by the Key Technologies Research andDevelopment Programof the Tenth five-year Plan of the Nation Scien-tific and Technological Development .(2001BA708B04-07) 

主　　题：glucosamine chitin ovariectomized rats bone strength osteoporosis osteohlast proliferation 

摘      要：This study intends to examine the effects of different concentrations of four kinds of degradations of chitin： glucosamine （GLC）, N-acetyl-D-glucosamine （NAG）, chitooligosaccharide（COS）, CM-chitooligosaccharide （CM-COS）—on the proliferation of MC3T3-E1 cell line cultured in vitro. Results suggest that all of the glucoses mentioned above promoted the proliferation of osteoblast, and various concentrations have different effects： the proliferation was remarkable when the concentration of GLC, NAG, COS, CM-COS was 100 , 100, 500, 500 μg/mL ,respectively. Furthermore we choose the glucosamine as the material and study the effect on the bone strength in ovariectomized rats. The results showed that the middle does of glucosamine can significantly increase the hone strength of femur in ovariectomized rats.