Antibacterial sorbicillin and diketopiperazines from the endogenous fungus Penicillium sp. GD6 associated Chinese mangrove Bruguiera gymnorrhiza
Antibacterial sorbicillin and diketopiperazines from the endogenous fungus Penicillium sp. GD6 associated Chinese mangrove Bruguiera gymnorrhiza作者机构:China State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China School of Biological Science and Technology University of Jinan Jinan 250022 China School of Life Science & Technology China Pharmaceutical University Nanjing 210009 China Syngenta Jealott's Hill International Research Centre Berkshire RG42 6EY United Kingdom
出 版 物:《Chinese Journal of Natural Medicines》 (中国天然药物(英文版))
年 卷 期:2018年第16卷第5期
页 面:358-365页
核心收录:
学科分类:0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 0703[理学-化学] 10[医学] 100602[医学-中西医结合临床]
基 金:supported by the Natural Science Foundation of China(No.81520108028) SCTSM Projects(Nos.14431901100 and 15431901000) the SKLDR/SIMM Project(No.SIMM1501ZZ-03)
主 题:Mangrove Penicillium sp. Sorbicillin derivative Diketopiperazine alkaloids
摘 要:One new sorbicillin derivative, 2-deoxy-sohirnone C(1), one new diketopiperazine alkaloid, 5 S-hydroxynorvalineS-Ile(2), and two naturally occurring diketopiperazines, 3 S-hydroxylcyclo(S-Pro-S-Phe)(3) and cyclo(S-Phe-S-Gln)(4), together with three known compounds were isolated from the Chinese mangrove endophytic fungus Penicillium sp. GD6. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison with literature data. The absolute configuration of 3-hydroxyl moiety in 3 was determined by Mosher s method, while the absolute stereochemistry of 2 and 4 was established by comparison with the CD spectra of natural and synthesized diketopiperazines. Compound 1 showed moderate antibacterial activity against Methicillin-resistant Staphylococcus aureus with a MIC value of 80 μg·m L^(-1).