Hyperinsulinemia and insulin resistance in a patient with type 2 diabetes complicated with myelofibrosis

作     者：Hidetaka Hamasaki Shuichi Mishima Hidekatsu Yanai 

作者机构：Department of Internal Medicine Kohnodai Hospital National Center for Global Health and Medicine Chiba 272-8516 Japan 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2012年第3卷第8期

页      面：156-157页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：The Grant of National Center for Global Health and Medicine  No. 22-120 

主　　题：Cytokines Hepatosplenomegaly Hyperinsulinemia Insulin resistance Myelofibrosis 

摘      要：Inflammation induces insulin resistance and hyperinsulinemia due to elevation of serum cytokines such as tumor necrosis factor-α and interleukins. Chronic myeloproliferative diseases including myelofibrosis show higher serum interleukin levels than healthy subjects, which has been suggested to be the useful markers for disease activity. However, an association between myelofibrosis and insulin resistance has not ever been discussed anywhere. Here we report a case of type 2 diabetes showing remarkable hyperinsulinemia and insulin resistance possibly due to myelofibrosis.