感觉运动性卒中早期恢复期内BOLD应答的变化

作     者：Binkofski F. Seitz R.J. 李一明 

作者机构：Department of Neurology Univ. Hospital Schleswig Holstein Campus Lübeck Germany Dr. 

出 版 物：《世界核心医学期刊文摘（神经病学分册）》 (Digest of the World Core Medical Journals:Clinical Neurology)

年 卷 期：2005年第1卷第3期

页      面：51-51页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：感觉运动性卒中 BOLD 缺血性卒中 经颅磁刺激 亚急性期 运动诱发电位 感觉运动皮质 慢性期 功能磁共振 电耦联 

摘      要：Background: The BOLD signal in functional MRI (fMRI) is closely related to neu ral activity. Objective: To investigate if this relationship is disrupted after ischemic stroke. Methods: BOLD activity during tactile exploration of objects wa s measured with fMRI at 1 week (subacute), 2 to 4 weeks (early chronic), and aft er 1 month (chronic) after the first completed brain infarction affecting the se nsorimotor cortex in eight patients. Functional integrity of the motor cortical output system was assessed with transcranial magnetic stimulation (TMS). Results : Early after infarction the BOLD response occurred in the adjacent cortical vi cinity related to finger movements of the affected hand. However, during the ear ly chronic stage there was a transient lack of this activation despite clinical improvement of hand function and preserved motor evoked potentials. The BOLD act ivity reappeared after further improvement in the chronic stage. Conclusions: Ou r findings suggest a transient hemodynamic electrical decoupling in the post i schemic cerebral cortex during the early phase of spontaneous clinical recovery.