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“静息事件相关”fMRI显示喉肌张力障碍患者感觉运动皮质激活减少

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世界核心医学期刊文摘（神经病学分册） 2006年第3期2卷 35-36页

作者： Haslinger B. Erhard P. Dresel C. 张殿增 Neurologische Klinik TU-MünchenMhlstrasse 28 D 81675 Munich Germany

Objective: To study with fMRI the pattern of sensorimotor activation in patients with spasmodic dysphonia (laryngeal dystonia) compared to healthy controls. Methods: The authors performed fMRI measurements during vocal motor tasks in 12 patients with laryngeal dystonia and compared them with those of 12 healthy volun teers. Patients were scanned before (pre) and after (post) treatment with local injections of botulinum toxin (BTX). They examined two different motor tasks: simple vocalization inducing dystonia and whispering without appearance of dystoni c symptoms. To avoid movement artifacts with oral motor tasks, the authors used a silent event-related fMRI approach involving noncontinuous sampling with no data acquisition during task performance. Results: They found reduced activation of primary sensorimotor as well as of premotor and sensory association cortices during voc alization in patients with laryngeal dystonia pre-BTX. This was partly observed also during the asymptomatic whispering task. BTX treatment did not result in r eversal of reduced cortical activation. Conclusion: fMRI signal is reduced in se nsorimotor cortices associated with movement of the affected body part in laryng eal dystonia, supporting a dystonic basis for this voice disorder.

关键词：感觉运动皮质张力障碍喉肌事件相关健康受试者痉挛性发音障碍扫描检查肉毒毒素不连续采样

在波罗的海肌阵挛性癫痫和进行性肌阵挛性癫痫中感觉运动皮质的兴奋性

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世界核心医学期刊文摘（神经病学分册） 2005年第5期1卷 42-43页

作者： Canafoglia L. Ciano C. Panzica F. S. Franceschetti 李宏建 C. Besta Natl . Neurologic Institute Via Celoria 11 20133 Milano Italy Dr.

Objective: To investigate whether Unverricht-Lundborg disease (ULD) and Laf ora body disease (LBD) can be differentiated on the basis of their neurophysiolo gic profiles. Methods: Somatosensory evoked potentials (SSEPs), long-loop refl exes (LLRs), and the influence of conditioning nerve stimulation on the motor po tentials evoked by transcranial stimulation in 8 patients with LBD and 10 patien ts with ULD were investigated. Results: Both groups showed sensorimotor cortex h yperexcitability, but their electrophysiologic profiles were different. Enlarged P25 to N33 SSEP components and enhanced LLRs were common in the ULD patients, w hereas medium-latency “ giant” SSEP components and less consistently enhanc ed LLRs were more frequently found in the patients with LBD. Cortical relay time was extremely brief in ULD but varied in LBD. Conditioning somatosensory stimul i differently affected motor cortex excitability, leading to early facilitation in ULD and delayed and prolonged facilitation in LBD. Conclusions: Patients with Unverricht-Lundborg disease (ULD) and Lafora body disease (LBD) have differen t electrophysiologic profiles. The ULD findings point to an aberrant subcortical or cortical loop (possibly short-cutting the somatosensory cortex) that is in volved in generating the prominent action myoclonus characterizing the disorder. The LBD findings highlight sustained hyperexcitability of the sensorimotor cort ex in response to afferent stimuli, which fit with a more severe impairment of i nhibitory mechanisms.

关键词：肌阵挛性癫痫感觉运动皮质躯体感觉感觉皮质神经生理学疾病特征皮质下生理学特征刺激参数种环

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期刊文摘

华中科技大学学报(医学版) 2007年第2期36卷 205-205页

颈椎病和长时间脊髓压迫病人脑萎缩、白质损伤和功能适应性改变的MRI证据

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国际医学放射学杂志 2020年第2期 245-246页

作者： á.Bernabéu-Sanz J.V.Mollá-Torró S.López-Celadal P.M.López E.Fernández-Jover 胡现宁 Magnetic Resonance Department Inscanner SL C/San Pedro Poveda

目的采用多种先进神经影像技术探讨颈椎病(CS)对脑的影响。方法纳入27例CS和24名年龄及性别匹配的健康对照者。采用改良的日本骨科协会评分系统

关键词：功能适应性 MRI 感觉运动皮质白质损伤颈椎病

大白鼠延髓网状结构的传入联系——HRP法研究

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武汉医学院学报 1983年第3期 211-214页

作者：卢金活彭汉林刘庆莹邓德忠童逸龄朱长庚武汉医学院基础医学部解剖教研室

多年以前,不少学者用Nauta氏溃变轴突银浸渍法研究并发现了延髓网状结构具有广泛的传入联系,有些已为神经生理学的研究所证实。唯这种方法因受实验手段的限制,在一次实验中,难以全面反映延髓网状结构的传入联系。近年来,由于辣根过氧

关键词：脑干网状结构红核对侧中脑盖传入联系家鼠属大白鼠 HRP 感觉运动皮质小脑顶核脑神经核纤维联系标记细胞丘脑下部中枢神经系统外侧区丘脑腹侧核外侧网状核

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缺血性脑白质病变的影像学评估

神经病学与神经康复学杂志 2006年第4期3卷 245-249页

作者：庄严沈加林上海交通大学医学院附属仁济医院放射科上海200127

　　概述　　随着CT、MR新技术的发展,神经影像学已不只是显示单纯的解剖结构,而且能够提供生理、生化等功能方面的信息.……

关键词：缺血性脑白质病变 DWI 脑梗死分水岭梗死超急性期 MRA PWI 梗死灶半球缺血半暗带感觉运动皮质脑缺血发作可逆性脑缺血髓鞘形成神经病学与神经康复学杂志影像学

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神经内科学重要新闻

当代医学 2001年第12期7卷 10-12页

作者：樊东升

Stroke,2001;32:1005报道:将大鼠骨髓成熟基质细胞事先取出后进行培养,在将大鼠制成缺血性脑卒中模型后,将已进行化学标记的培养细胞分别于年中后第1d和第7d经静脉回输大鼠各1次,以未进行骨髓移植的卒中大鼠作对照,分别于卒中前及卒中后... 详细信息

Stroke,2001;32:1005报道:将大鼠骨髓成熟基质细胞事先取出后进行培养,在将大鼠制成缺血性脑卒中模型后,将已进行化学标记的培养细胞分别于年中后第1d和第7d经静脉回输大鼠各1次,以未进行骨髓移植的卒中大鼠作对照,分别于卒中前及卒中后第1、7、35d观察两组行为学和免疫组化结果的差异。结果发现,接受骨髓移植治疗组大鼠

关键词：卒中后左旋多巴特发性震颤卡巴拉汀痴呆病人脑卒中病人脑卒中再发缺血性脑卒中行为症状感觉运动皮质布洛芬偏头痛脑病精神病性症状缺血性卒中新闻

多发性硬化症患者运动活性的纵向fMRI研究

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世界核心医学期刊文摘（神经病学分册） 2005年第12期1卷 25-26页

作者： Pantano P. Mainero C. Lenzi D. 袁海峰 Dept. Neurological Sciences University of Rome 'La Sapienza' Viale dell'Università30 I-00185 RomeItaly

Using functional MRI (fMRI), patients with multiple sclerosis showed a greater extent of motor activation than controls. Although functional changes are often interpreted as adaptive and as a contributing factor in limiting the clinical deficit, no longitudinal studies have yet been performed for multiple sclerosis. Sixteen patients with multiple sclerosis, two patients with possible multiple sclerosis and nine age-matched controls underwent two fMRI studies with a time interval of 15-26 months. The motor task consisted of a self-paced sequential finger opposition movement with the right hand. Patients with multiple sclerosis exhibited greater bilateral activation than controls in both fMRI studies. At follow-up, patients showed a reduction in functional activity in the ipsilateral sensorimotor cortex and in the contralateral cerebellum. No significant differences between the two fMRI studies were observed in controls. Activation changes in ipsilateral motor areas correlated inversely with age, extent and progression of T1 lesion load, and occurrence of a new relapse. This study may help the understanding of the evolution of brain plastic changes in multiple sclerosis indicating that, in younger patients with a less structural brain damage and benign clinical course, the brain reorganizes its functional activity towards a more lateralized pattern of brain activation. The tendency towards a normalization of brain functional activity is hampered in older patients and in those developing relapses or new irreversible brain damage.

关键词：多发性硬化症 fMRI研究感觉运动皮质功能磁共振成像脑损伤患者脑功能活动临床病程可塑性变化负相关显著性差异

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脑梗塞后的功能恢复

国际脑血管病杂志 1995年第6期3卷 331-332页

作者：梁玉宏

作者通过文献复习,讨论了影响实验性脑缺血后功能恢复的有关因素。自发性功能恢复仅少数研究对局限性脑缺血后行为功能的恢复作了统计学评估。鼠大脑中动脉(MCA)闭塞后16周内存在学习行为障碍,神经功能缺失和运动协调的损害是在第2和... 详细信息

作者通过文献复习,讨论了影响实验性脑缺血后功能恢复的有关因素。自发性功能恢复仅少数研究对局限性脑缺血后行为功能的恢复作了统计学评估。鼠大脑中动脉(MCA)闭塞后16周内存在学习行为障碍,神经功能缺失和运动协调的损害是在第2和第4周。双侧

关键词：功能恢复感觉运动皮质触觉障碍