Effects of methylprednisolone or immunoglobulin when added to standard treatment with intravenous azithromycin for refractory Mycoplasma pneumoniae pneumonia in children
Effects of methylprednisolone or immunoglobulin when added to standard treatment with intravenous azithromycin for refractory Mycoplasma pneumoniae pneumonia in children作者机构:Department of Pediatric PulmonologyShengjing Hospital of China Medical UniversityShenyangChina China Medical UniversityShenyangChina
出 版 物:《World Journal of Pediatrics》 (世界儿科杂志(英文版))
年 卷 期:2017年第13卷第4期
页 面:321-327页
核心收录:
学科分类:1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金:This study was funded by Natural Science Foundation of Liaoning Province of China(2013021017)
主 题:immunoglobulin methylprednisolone refractory Mycoplasma pneumoniae pneumonia
摘 要:Background:The prevalence of Mycoplasma pneumoniae pneumonia has increased considerably in recent *** evaluate the efficacy of combined treatment of azithromycin with intravenous immunoglo-bulin (IVIG) or methylprednisolone in children with refractory Mycoplasma pneumoniae pneumonia (RMPP).Methods:Children with RMPP were randomly allocated to group A [intravenous azithromycin (IA)+ methylprednisolone],group B (IA+IVIG) or group C (IA alone).Following a 7-day treatment,group C patients were randomly separated into two sub-groups:group C1 (IA+methylprednisolone) and group C2 (IA+IVIG).Temperature,respiratory symptoms and signs were *** average febrile period after treatment (F2),average total febrile period (F3),infiltration absorption,atelectasis resolution,pleural effusion disappearance were *** levels of C-reactive protein (CRP),D-dimer,and lactate dehydrogenase (LDH) were ***:Seven days after enrollment,the average F2 after treatment of group A was the *** with the control group C,the combined treatment group A and B showed higher rates of infiltration absorption,atelectasis resolution and pleural effusion disappearance,while lower levels of serum CRP,D-dimer and *** days after enrollment,all children with combined therapy clinically improved,and presented better laboratory *** C1 showed shorter F3 and lower levels of CRP and LDH than those of group ***,group A showed the shortest F3,also has the lowest CRP and ***:Azithromycin with IVIG or methylprednisolone was better treatment for children with RMPP than azithromycin *** treatment may be beneficial,especially when the efficacy of corticosteroids is insecure,thus could be considered as an alternative of primary therapeutic approaches.