Effects of methylprednisolone or immunoglobulin when added to standard treatment with intravenous azithromycin for refractory Mycoplasma pneumoniae pneumonia in children

作     者：Li-Shen Shan Xin Liu Xin-Yuan Kang Fei Wang Xiao-Hua Han Yun-Xiao Shang 

作者机构：Department of Pediatric PulmonologyShengjing Hospital of China Medical UniversityShenyangChina China Medical UniversityShenyangChina 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2017年第13卷第4期

页      面：321-327页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This study was funded by Natural Science Foundation of Liaoning Province of China(2013021017) 

主　　题：immunoglobulin methylprednisolone refractory Mycoplasma pneumoniae pneumonia 

摘      要：Background:The prevalence of Mycoplasma pneumoniae pneumonia has increased considerably in recent *** evaluate the efficacy of combined treatment of azithromycin with intravenous immunoglo-bulin (IVIG) or methylprednisolone in children with refractory Mycoplasma pneumoniae pneumonia (RMPP).Methods:Children with RMPP were randomly allocated to group A [intravenous azithromycin (IA)+ methylprednisolone],group B (IA+IVIG) or group C (IA alone).Following a 7-day treatment,group C patients were randomly separated into two sub-groups:group C1 (IA+methylprednisolone) and group C2 (IA+IVIG).Temperature,respiratory symptoms and signs were *** average febrile period after treatment (F2),average total febrile period (F3),infiltration absorption,atelectasis resolution,pleural effusion disappearance were *** levels of C-reactive protein (CRP),D-dimer,and lactate dehydrogenase (LDH) were ***:Seven days after enrollment,the average F2 after treatment of group A was the *** with the control group C,the combined treatment group A and B showed higher rates of infiltration absorption,atelectasis resolution and pleural effusion disappearance,while lower levels of serum CRP,D-dimer and *** days after enrollment,all children with combined therapy clinically improved,and presented better laboratory *** C1 showed shorter F3 and lower levels of CRP and LDH than those of group ***,group A showed the shortest F3,also has the lowest CRP and ***:Azithromycin with IVIG or methylprednisolone was better treatment for children with RMPP than azithromycin *** treatment may be beneficial,especially when the efficacy of corticosteroids is insecure,thus could be considered as an alternative of primary therapeutic approaches.