Brucellosis and tuberculosis:Clinical overlap and pitfalls

作     者：Sowjanya Dasari Kushal Naha Mukhyaprana Prabhu 

作者机构：Department of MedicineKasturba HospitalManipal-576 104KarnatakaIndia 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2013年第6卷第10期

页      面：823-825页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Brucellosis Tuberculosis Overlap Drug resistance 

摘      要：Objective:To identify characteristic features of tuberculosis in patients with culture proven ***:A retrospective analysis was performed on patients diagnosed with culture proven brucellosis between January and December 2011,based on review of their medical *** with demonstrable co-infection with tuberculosis were *** features,laboratory parameters and tissue histopathology reports where available were ***:Thirty-two patients with brucellosis were included in the ***-one(65.63%)patients had chronic fever,thirteen(40.63%)had a productive cough,while significant weight loss,evening rise of temperature and night sweats were reported by eight(25.00%),eleven(34.38%)and five(15.63%)patients ***(28.13%)patients had at least three of these ***,hepatomegaly and splenomegaly were noted on examination in seven(21.88%),fifteen(46.88%)and twelve(37.50%)patients ***(25.00%)patients had hepatosplenomegaly,of these only two had associated significant *** examination was normal in all *** ESR greater than 50 mm/hr was seen in eight(25.00%),it was greater than 100 mm/hr in five(15.63%)*** was seen in eight(25.00%)*** marrow biopsy showed non-caseating granulomas in three(9.38%)cases,lymph node biopsy showed granulomas in one ***,three(9.38%)patients had known risk factors for tuberculosis,while six(18.75%)had risk factors for ***:There is a clear overlap between brucellosis and tuberculosis both in terms of clinical presentation and laboratory *** is essential to c-arefully rule out tuberculosis in all cases of suspected or proven brucellosis before initiating antimicrobial therapy,in order to forestall development of drug-resistant tuberculosis.