Hedgehog in the Drosophila testis niche:what does it do there?

作     者：Zhao Zhan Chenyu Pan Yun Zhao 

作者机构：State Key Laboratory of Cell BiologyInstitute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2013年第4卷第9期

页      面：650-655页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the National Basic Research Program(973 Program)(Nos.2010CB912101 and 2011CB943902) the National Natural Science Foundation of China(Grant No.31171414) 

主　　题：Drosophila testis stem cell Hedgehog JAK-STAT 

摘      要：Stem cell niche is a specialized microenvironment crucial to *** testis in Drosophila contains two dif-ferent types of stem cells,the germline stem cells and the somatic cyst stem cells that are sustained by their respec-tive niche signals,thus is a good system for studying the interaction between the stem cells and their hosting *** JAK-STAT and BMP pathways are known to play critical roles in the self-renewal of different kinds of stem cells,but the roles of several other pathways have emerged recently in a complex signaling network in the testis *** of independent observations from three research groups have uncovered an important role of Hedgehog(Hh)in the Drosophila testis *** this review,we summarize these recent fi ndings and discuss the interplay between the Hh signaling mechanisms and those of the JAK-STAT and BMP *** also dis-cuss directions for further investigation.