Cardioprotective effect of Danshen injectable powder on pressure overloadinduced ventricular remodeling in rats and isoproterenol induced myocardial injury in mice

作     者：Jia-min XU Yi SUN Xin ZHAO Xiao-ping PU 

作者机构：National Key Research Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100191 China Department of Molecular and Cellular Pharmacology School of Pharmaceutical Sciences Peking University Beijing 100191 China 

出 版 物：《中国药理学与毒理学杂志》 (Chinese Journal of Pharmacology and Toxicology)

年 卷 期：2018年第32卷第4期

页      面：318-319页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100602[医学-中西医结合临床] 10[医学] 

主　　题：丹参 心肌缺血 治疗方法 临床分析 

摘      要：OBJECTIVE To determine the effects of Danshen injectable powder on myocardial remodeling in pressure overload rats and isoproterenol(ISO) injection *** SD Rats were subject to abdominal aortic constriction(AAC) surgery to develop pressure *** effect of Danshen injectable powder was assessed six weeks after AAC *** lactic dehydrogenase(LDH) and creatine kinase(CK) levels in serum,biometric,echocardiographic parameters,interstitial fibrosis,the expression of DJ-1 and SOD2 were then *** myocardial impairment in mice was induced by ISO *** and CK in serum,biometric,interstitial fibrosis were measured to investigate the cardioprotective effect of Danshen injectable ***-assisted laser desorption mass spectrometry imaging(MALDI-MSI) was used to detect the changes of 60-1000 Da molecules in mice heart *** In AAC rats,we observed compensatory hypertrophy and perivascular fibrosis,however cardiac function had not progressed to *** levels of LDH and CK were decreased significantly in the Danshen injectable powder groups(P0.05,P0.05).Danshen injectable powder could alleviate the perivascular collagen deposits but not cardiac hypertrophy in AAC ***,Danshen injectable powder enhanced the expression levels of SOD2 and DJ-1 in ***(P0.05,P0.01).In ISO injection mice,the levels of HWI and LDH were decreased *** in drug treatment group compared with model group(P0.01,P0.01).In the MALDI-MSI of mice heart section,Danshen injectable powder can improve the reduction of energy metabolism-related substances including adenosine,creatine and ADP induced by ISO *** Danshen injectable powder can attenuate perivascular fibrosis and improve the expression of antioxidative stress-related proteins SOD2,DJ-1 in the rats with pressure overload-induced left ventricular *** injectable powder has cardioprotective effect on ISO impairment in m