Processing and Mechanical Characterization of Electro-spun Polycaprolactone Membrane Coated Hernia Mesh

作     者：SHEN Jiali ZHANG Peihua LU Yao 沈嘉丽;张佩华;鲁瑶

作者机构：Key Laboratory of Textile Science ＆ Technology Ministry of Education College of Textiles Donghua University Shanghai 201620 China 

出 版 物：《Journal of Donghua University(English Edition)》 (东华大学学报（英文版）)

年 卷 期：2018年第35卷第1期

页      面：65-69页

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：Biomedical Textile Materials Science and Technology(111 Project) China(No.B07024) 

主　　题：composite hernia mesh electro-spinning biomedical membrane polycaprolactone(PCL) 

摘      要：Composite hernia meshes designed in this paper consist of polypropylene( PP) knitted meshes and polycaprolactone( PCL)nanofiber membranes,which are produced by electro-spinning the solution composed of PCL as a solute and the mixture of dimethylformamide( DMF) and dichloromethane( DCM) as a solvent. The morphology and diameter of nanofibers in the membrane are well performed when the 15% PCL solution is electrospun under the condition of 18 k V,15 cm,0. 7 m L/h. The poresize of the membranes is less than 10 μm, where such kinds of arrangement are extremely compact to prevent the cells from growing in. The mechanical properties of the membrane with better arrangement state can reach 68. 8 c N/mm^2. The cytotoxicity test of the composite mesh demonstrates the nontoxicity of the ***,the bonding fastness between the membrane and the PP mesh is extremely unsubstantial. The better ways to bond PP mesh with PCL membranes should be discussed in the future.