Electrospun Chitosan( CS)/Poly( L-lactic-co-ε-caprolactone)( PLCL ) Nanofibers and Their Potential as Small-Diameter Vascular Scaffold

作     者：TAO Ling WANG Weizhong LIU Dinghua DU Haibo ZHANG Qianqian CHEN Liang HE Chuanglong 陶玲;王伟忠;刘顶华;杜海波;张骞骞;陈良;何创龙

作者机构：College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China 

出 版 物：《Journal of Donghua University(English Edition)》 (东华大学学报（英文版）)

年 卷 期：2018年第35卷第1期

页      面：32-37页

学科分类：0817[工学-化学工程与技术] 08[工学] 0807[工学-动力工程及工程热物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0802[工学-机械工程] 0811[工学-控制科学与工程] 

基　　金：National Natural Science Foundations of China(Nos.31771048,31570984,31271028) International Cooperation Fund of the Science and Technology Commission of Shanghai Municipality,China(No.15540723400) Biomedical Textile Materials Science and Technology(111 Project),China(No.B07024) 

主　　题：electrospinning chitosan(CS) ploy(L-lactic-co-ε-caprolactone)(PLCL) vascular scaffolds 

摘      要：The ideal small-diameter vascular grafts should mimic the nanostructure and mechanical properties of nature blood vessel. In this study, electrospun chitosan( CS)/poly( L-lactic-co-ε-caprolactone)( PLCL) nanofibers were developed for potential small-diameter blood vessel applications. CS is a positively charged polymer which is beneficial for cell attachment and growth,while PLCL provides favorable mechanical support due to its excellent elasticity. Typical nanofibrous structure was observed in both CS/PLCL and pure PLCL scaffolds. The optimal mechanical property could be achieved when the weight ratio of CS/PLCL was 1 ∶ *** with pure PLCL scaffolds, the CS/PLCL scaffolds showed higher hydrophilicity and markedly promoted the attachment,spreading and proliferation of human umbilical vein endothelial cells( HUVECs). Hence,CS/PLCL scaffolds can be used as potential vascular grafts.