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Hydrothermal growth of whitlockite coating on β-tricalcium phosphate surfaces for enhancing bone repair potential

Hydrothermal growth of whitlockite coating on β-tricalcium phosphate surfaces for enhancing bone repair potential

作     者:Xiaoheng Guo Xiao Liu Huichang Gao Xuetao Shi Naru Zhao Yingjun Wang 

作者机构:School of Materials Science and Engineering South China University of Technology Guangzhou 510641 China Notional Engineering Research Centre for Tissue Restoration and Reconstruction Guangzhou 510006 China Guangdong Province Key Laboratory of Biomedical Engineering South China University of Technology Guangzhou 510006 China school of Medicine South China University of Technology Guangzhou 510006 China 

出 版 物:《Journal of Materials Science & Technology》 (材料科学技术(英文版))

年 卷 期:2018年第34卷第6期

页      面:1054-1059页

核心收录:

学科分类:0806[工学-冶金工程] 0817[工学-化学工程与技术] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程(可授工学、理学学位)] 080502[工学-材料学] 0703[理学-化学] 0802[工学-机械工程] 0702[理学-物理学] 0801[工学-力学(可授工学、理学学位)] 

基  金:financially supported by the National Basic Research Programme of China(Grant No.2012CB619100) the National Natural Science Foundation of China(Grant Nos.51232002and 51603074) the Science and Technology Programme of Guangzhou city(Grant No.201607010234) the Fundamental Research Funds for the Central Universities(Grant No.2015ZZ009) Guangdong Natural Science Funds for Distinguished Young Scholar(Grant No.2016A030306018) 

主  题:Surface Whitlockite Hydrothermal reaction Bone repair 

摘      要:In this study, we developed a simple approach for the controllable growth of whitlockite (WH) on a β- tricalcium phosphate surface and investigated its cell viability via CCK-8, its live-dead staining and its alkaline phosphatase activity. Herein, WH with controllable morphologies was prepared by regulating the hydrothermal reaction conditions. The results of scanning electron microscopy, X-ray diffraction and X- ray photoelectron spectroscopy indicated that pure hexagonal plates of WH were prepared successfully. In vitro cell experiments showed that WH possessed excellent biocompatibility and effectively promoted the adhesion and proliferation of mouse bone mesenchymal stem cells. The osteogenesis of the WH was also enhanced. The obtained WH was expected to be utilized for promising applications as implantable block materials for bone repair.

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