Proton leakage is the mechanism for hematoporphyrin photosensitization-promoted inactivation of rat liver mitochondria
Proton leakage is the mechanism for hematoporphyrin photosensitization-promoted inactivation of rat liver mitochondria作者机构：Beijing 100080 China Chinese Academy of Sciences Dpartment of Biocbemistry Institute of Zoology State Key Laboratory of Biomembrane and Membrane Biotechnology The Second Military University of Medical Science Shanghai 200433
出 版 物：《Progress in Natural Science:Materials International》 (自然科学进展·国际材料(英文))
年 卷 期：1995年第4期
学科分类：0710[理学-生物学] 07[理学] 071003[理学-生理学]
主 题：hematoporphyrin photosensitization mitochondria singlet oxygen proton leakage.
摘 要：The effects of hematoporphyrin photosensitization on the energy-transducing functions of isolated rat liver mitochondria have been studied. By using the measurements of the illumination time-and hematoporphyrin concentration-dependent variations of bioenergetical parameters of mitochondria, it is shown clearly that the photosensitization-promoted proton leakage of inner mitochondrial membrane, together with the resultant dissipation of proton electrochemical gradient, is the mechanism leading to the impairment of oxidative phosphorylation of mitochondria.
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