Metabolomics of gastric cancer metastasis detected by gas chromatography and mass spectrometry
Metabolomics of gastric cancer metastasis detected by gas chromatography and mass spectrometry作者机构：Department of Gastroenterology Shanghai Sixth People's Hospital Shanghai Jiao Tong University 600 Yishan Road Shanghai 200233 China. wqq_021002@***
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2010年第16卷第46期
页 面：5874-5880页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by Grants from Shanghai Key Program of Science and Technology Committee(09JC1411600) Shanghai Natural Science Foundation(08ZR1411300)
主 题：Gastric cancer Metastasis Metabolite Metabolomics Gas chromatography and mass spectrometry
摘 要：AIM:To elucidate the underlying mechanisms of metastasis and to identify the metabolomic markers of gastric cancer ***:Gastric tumors from metastatic and nonmetastatic groups were used in this *** and different metabolic patterns were analyzed by gas chromatography,mass spectrometry and principal components analysis (PCA),*** performance was validated by the area under the curve (AUC) of receiver operating characteristic ***:Twenty-nine metabolites were differentially expressed in animal models of human gastric *** the 29 metabolites,20 were up-regulated and 9 were down-regulated in metastasis group compared to non-metastasis *** models from the metabolite profiles could differentiate the metastatic from the nonmetastatic specimens with an AUC value of *** metabolites were mainly involved in several metabolic pathways,including glycolysis (lactic acid,alaline),serine metabolism (serine,phosphoserine),proline metabolism (proline),glutamic acid metabolism,tricarboxylic acid cycle (succinate,malic acid),nucleotide metabolism (pyrimidine),fatty acid metabolism (docosanoic acid,and octadecanoic acid),and methylation(glycine).The serine and proline metabolisms were highlighted during the progression of ***:Proline and serine metabolisms play an important role in *** metabolic profiling of tumor tissue can provide new biomarkers for the treatment of gastric cancer metastasis.
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