Enhancement of oral bioavailability and immune response of Ginsenoside Rh2 by co-administration with piperine

作     者：JIN Zhao-Hui QIU Wen LIU Hui JIANG Xue-Hua WANG Ling 

作者机构：West China School of Pharmacy Sichuan University Chengdu 610041 China Department of Pharmacy West China Hospital Chengdu 610041 China Lanzhou University Second Hospital Lanzhou 730030 China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2018年第16卷第2期

页      面：143-149页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.81573789) 

主　　题：Panax Ginseng Ginsenoside Rh2 Piperine Immune modulation Bioenhaneer 

摘      要：Ginsenoside Rh2(Rh2)is one of the major bioactive ginsenosides in Panax ***,the oral bioavailability of Rh2 is low,with P-glycoprotein(P-gp)and CYP3A4 being reported to be the main *** purpose of the present study was to determine the enhancing effect of piperine on the oral bioavailability as well as bioactivity of *** inhibitory effect of piperine on P-gp and CYP3A4 was determined using a Caco-2 monolayer model and a recombinant CYP3A4 metabolic system,*** pharmacokinetics of oral Rh2(10 mg·kg^(-1))administered alone or in combination with piperine(10 and 20 mg·kg^(-1))was performed in *** immune boosting effect of Rh2 was assessed in rats by measuring IL-12 level after treated by Rh2 alone or co-administered with *** results indicated that piperine significantly increased the permeability of Rh2 and inhibited the metabolism of *** pharmacokinetic study results showed that the AUC of Rh2 was significantly increased in combination with piperine at high dose(20 mg·kg^(-1))when compared to the control group,with relative bioavailability of 196.8%.The increase of Rh2 exposure led to increased serum levels of *** conclusion,piperine may be used as a bioenhancer to improve pharmacological effect of Rh2 when given orally.