Design of antibacterial peptide-like conjugated molecule with broad spectrum antimicrobial ability

作     者：Hui Chen Meng Li Zhang Liu Rong Hu Shengliang Li Yuan Guo Fengting Lv Libing Liu Yilin Wang Yuanping Yi Shu Wang 

作者机构：Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Key Laboratory of Colloid Interface and Chemical Thermodynamics Institute of ChemistryChinese Academy of Sciences 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2018年第61卷第1期

页      面：113-117页

核心收录：

学科分类：07[理学] 08[工学] 

基　　金：supported by the National Natural Science Foundation of China (21533012, 21473220) Strategic Priority Research Program of the Chinese Academy of Sciences (XDA09030306) 

主　　题：OFBT broad spectrum antimicrobial activity 

摘      要：Increasing multidrug-resistant （MDR） superbugs emerge worldwide causing a public health crisis. Consequently, it is urgent to find new antibiotics with efficient broad-spectrum antimicrobial activity. By virtue of versatility in molecular design, a new peptide-like cell membrane-broken molecule, oligo-（7,7＇-bifluoren-benzo[c][1,2,5]thiadiazole） （OFBT） possessing a conjugated backbone and eight pendant guanidyl moieties was designed and synthesized. OFBT exhibits favorable broad-spectrum of antirnicrobial activity to pathogens including Gram-negative and Gram-positive bacteria, and fungi with the minimum inhibitory concentration （MIC） below 3.0 μM. Moreover, OFBT exhibits high selectivity for pathogens over human cells to make it a promising broad spectrum antimicrobial agent.