Relationship between the -455G/A and -148C/T polymorphisms in the beta-fibrinogen gene and cerebral infarction in the Xinjiang Uygur and Han Chinese populations

作     者：Xiaoning Zhang Yanyun Li Xuebing Guo Lei Du Jianhua Ma 

作者机构：Department of Neurology First Affiliated Hospital of Xinjiang Medical University Urumqi 830054 Xinjiang Uygur Autonomous Region China Hospital of Xinjiang Production and Construction Corps Urumqi 830000 Xinjiang Uygur Autonomous Region China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2012年第7卷第7期

页      面：546-551页

核心收录：

学科分类：0710[理学-生物学] 0821[工学-纺织科学与工程] 07[理学] 08[工学] 071007[理学-遗传学] 082104[工学-服装设计与工程] 

基　　金：supported by the National Natural Science Foundation of China  No. 81060097 

主　　题：Uygur Han cerebral infarction β-fibrinogen gene polymorphism neural regeneration 

摘      要：We sought to investigate the correlation between the -455G/A and -148C/T polymorphisms of the β-fibrinogen gene and plasma fibrinogen levels in patients with cerebral infarction and in healthy subjects among the Xinjiang Uygur and Han Chinese populations, by using polymerase chain reaction-restriction enzyme digestion analysis. Results showed that there were no statistically significant differences in the distributions of the -455G/A genotype and allele frequency between the Uygurs and the Han. Plasma fibrinogen levels in cerebral infarction patients among the Uygurs and the Han were higher than those among healthy subjects. In particular, the frequencies of the -455G/A AA and -148C/T TT genotypes were significantly higher than in healthy subjects. Individuals carrying the A or T allele had a higher incidence of cerebral infarction compared with those carrying the G or C allele. Our experimental findings indicate that the -148C/T and -455G/A polymorphisms are associated with cerebral infarction in Xinjiang Uygur and Han Chinese subjects. The susceptibility- conferring alleles are -148T and -455A, and the susceptibility-conferring genotype is -455G/A ＋ AA.