植物雌激素可提高体外受精胚-胎移植过程的妊娠率:一项前瞻性、随机对照试验
Phytoestrogens may improve the pregnancy rate in in vitro fertilization -embryo transfer cycles: A prospective, controlled, randomized trial出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)
年 卷 期：2005年第1卷第5期
页 面：27-27页
学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
主 题：体外受精 移植过程 随机对照试验 植物雌激素 黄体期 降调节 着床率 自然流产率 卵母细胞 妊娠试验
摘 要：To compare the effectiveness of IM P and IM P plus oral phytoestrogens for lut eal phase support in patients undergoing IVF-ET cycles. Prospective, controlled , randomized trial. University Hospital, Perugia, Italy. Two hundred thirteen in fertile patients undergoing IVF-ET were included in the study. The inclusion cr iteria were use of a GnRH agonist for pituitary down-regulation and age 40 ye ars. The total number of cycles performed was 274. Patients were assigned to rec eive either IM P (50 mg daily) plus placebo or P (50 mg daily) plus phytoestroge n supplementation (1,500 mg daily) for luteal phase support starting from the ev ening of oocyte retrieval until either a serum pregnancy test result was negativ e or embryonic heartbeat was sonographically confirmed. The outcomes of IVF-ET were evaluated in both study groups in terms of implantation rate, biochemical p regnancy rate (PR), clinical PR, spontaneous abortion rate, and ongoing pregnanc y/delivered rate. Statistically significant higher values for implantation rate, clinical PR, and ongoing pregnancy/delivered rate were recorded in the patients who received P plus phytoestrogens for luteal phase support in comparison with patients receiving P and placebo. Although the results of this study encourage t he use of phytoestrogens for luteal phase support in patients undergoing IVF-ET program, more studies are necessary to support the hypothesis that phytoestroge ns have a beneficial effect in IVF cycles.
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